Chinese Journal of Tissue Engineering Research

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EIectroacupuncture effects on bladder capacity and tissue morphology of the neurogenical bladder after sacral spinal cord injury

Li Jing-xing1, Zhang Hong2, Ai Kun2, Zhang Yu-chen2, Kuang Jing-zhi2, Bao Qiu-ying2   

  1. 1Rehabilitation Center for Children, Hengyang Central Hospital, Hengyang  421000, Hunan Province, China; 2College of Acupuncture, Moxibustion and Massage, Hunan University of Traditional Chinese Medicine, Changsha  410007, Hunan Province, China
  • Revised:2013-10-17 Online:2013-12-10 Published:2013-12-10
  • Contact: Zhang Hong, M.D., Professor, Doctoral supervisor, College of Acupuncture, Moxibustion and Massage, Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China zh5381271@qq.com
  • About author:Li Jing-xing★, Master, Physician, Rehabilitation Center for Children, Hengyang Central Hospital, Hengyang 421000, Hunan Province, China 283962818@qq.com
  • Supported by:

    the Natural Science Foundation of Hunan Province, No. 13JJ3098*; the Major Project of Hunan Provincial Administration of Traditional Chinese Medicine, No. 201109*; the Research Project of Hunan Provincial Education Bureau, No. 1200264*

Abstract:

BACKGROUND: Spinal cord injuries induced by sacral segment and lumbar lesions can damage the primary sacral micturition center or its surrounding nerves (parasympathetic and somatic nerve) to cause detrusor areflexia, thereby leading to urinary retention and further pathological changes in bladder tissue morphology.
OBJECTIVE: To observe the effects of electroacupuncture at the Ciliao (BL32), Zhongji (RN3), Sanyinjiao (SP6) acupoints on bladder capacity and bladder tissue morphology of rats with urinary retention after sacral spinal cord injury.
METHODS: Ten of 40 female Sprague-Dawley rats were randomly selected as blank group, and other 30 rats were randomly divided into model group, acupoint group and non-acupoint group. In the model group, the rats received no electroacupuncture. In the non-acupoint group, acupuncture and electroacupuncture at non-acupoint points were performed, respectively, for 20 minutes. In the acupoint group, acupuncture and electroacupuncture were performed at the Ciliao, Zhongji, and Sanyinjiao acupoints. Bladder capacity was measured at days 14 and 22 after treatment. After treatment, bladder tissues were extracted for morphological observation with hematoxylin-eosin staining.
RESULTS AND CONCLUSION: (1) The maximum bladder capacity in the acupoint group was obviously reduced after treatment (P < 0.01); the curative effect in the acupoint group was more obvious than the non-acupoint group (P < 0.05); the difference between preoperative and postoperative bladder capacity (d value) was more significant in the acupoint group than the non-acupoint group (P < 0.05). (2) Compared with the model and non-acupoint groups, morphological changes in the bladder tissue were improved more significantly in the acupoint group. These findings indicate that electroacupuncture at the Ciliao, Zhongji, and Sanyinjiao acupoints can effectively reduce the maximum bladder capacity and repair the damaged bladder tissue after sacral spinal cord injury.



中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

Key words: electroacupuncture, acupuncture points, urinary bladder, spinal cord injuries, urinary retention

CLC Number: