Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (49): 8602-8607.doi: 10.3969/j.issn.2095-4344.2013.49.022

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Autologous stem cells transplantation in the treatment of critical limb ischemia

Li Mao, Huang Wen   

  1. First Affiliated Hospital of Chongqing Medical University, Chongqing  400016, China
  • Revised:2013-09-02 Online:2013-12-03 Published:2013-12-03
  • Contact: Huang Wen, M.D., Chief physician, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China dhuangwen@hotmail.com
  • About author:Li Mao★, Studying for master’s degree, Attending physician, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China limao19750204@126.com
  • Supported by:

    the General Program of National Natural Science Foundation of China, No. 81070255*

Abstract:

BACKGROUND: Critical limb ischemia is difficult to be treated among the peripheral arterial occlusive diseases, and the application of transplanting autologous stem cells can bring a hope for the treatment of this disease.
OBJECTIVE: To review the autologous stem cells transplantation in the treatment of critical limb ischemia at present, and to study the mechanism and the existing problems.
METHODS: A computer retrieval of PubMed database, Wanfang database, and CNKI database was conducted to search the related articles with the keywords of “stem cell, transplant, critical limb ischemia” in English and Chinese. Finally, 47 articles were included in final analysis according to the inclusion criteria.
RESULTS AND CONCLUSION: Autologous stem cells transplantation for treatment of lower extremity ischemic disease is a latest and significantly effective treatment, but the mechanism is unclear and still needs further study.


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程


全文链接:

Key words: stem cells, stem cell factor, cytokines, lower extremity, ischemia, vascular patency, vascular diseases

CLC Number: