Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (27): 5103-5106.doi: 10.3969/j.issn.1673-8225.2010.27.038

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Effects of endothelial progenitor cells in treatment of vascular-related diseases

Lu Jing-Jing1, Yang Zhen-dong1, Wang Gui-min2   

  1. 1 Postgraduate Department, Liaoning Medical University, Jingzhou 121001, Liaoning Province, China; 2 Department of Traditional Chinese Medicine, First Affiliated Hospital of Liaoning Medical University, Jinzhou  121001, Liaoning Province, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Wang Gui-min, Professor, Department of Traditional Chinese Medicine, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China wangguimin4197197@yahoo.com.cn
  • About author:Lu Jing-jing★, Studying for master’s degree, Postgraduate Department, Liaoning Medical University, Jingzhou 121001, Liaoning Province, China ljjff241@sina.com

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Abstract:

BACKGROUND: Endothelial progenitor cells have been extensively applied to the treatment of vascular-related diseases in recent years, due to its high proliferation potential and multidirectional differentiation.
OBJECTIVE: To summarize the research progress of endothelial progenitor cells in treatment of vascular-related diseases.
METHODS: We retrieved PubMed Database for relevant articles published from January 2004 to September 2009. The key words were “endothelial progenitor cells, vascular-related disease” in English. Simultaneously, a computer-based search was performed in Tsinghua Tongfang Full Text Database for relevant articles published from January 2004 to September 2009. The key words were “endothelial progenitor cells, vascular-related disease” in Chinese. The literatures were classified according to inclusion and exclusion criteria by the first and second authors. Its contents and results were evaluated. Finally, a total of 30 articles were included.
RESULTS AND CONCLUSION: Endothelial progenitor cells are a vascular endothelial precursor cells. It has been confirmed that endothelial progenitor cells are not only involved in vasculogenesis in embryonic period, but also participate in angiogenesis after birth. It is in a dynamic equilibrium state between endothelial damage and the repair effects of surrounding mature endothelial cells and endothelial progenitor cells to vascular endothelial in normal circumstances. In pathological conditions, the function of proliferation and migration, adhesion of endothelial progenitor cells are all weaker than before, leading to that vascular endothelial injury cannot be repaired or damaged, thus become an important dangerous factor in many vascular-related diseases. Endothelial progenitor cells have great application value and prospect in treatment of vascular-related diseases and deserve further investigations.

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