Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (14): 2627-2630.doi: 10.3969/j.issn.1673-8225.2010.14.033

Previous Articles     Next Articles

Role of bone morphogenetic protein 2 and DLX5 in the differentiation of neural stem cells from anterior subventricular zone into neurons

Liu Sheng-hua, Zhou Zheng, Feng Bao-hai   

  1. Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing  400037, China
  • Online:2010-04-02 Published:2010-04-02
  • Contact: Zhou Zheng, Doctor, Professor, Chief physician, Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing 400037, China bigbrain126@yahoo.com.cn
  • About author:Liu Sheng-hua★, Studying for master’s degree, Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing 400037, China Lg65036@126.com
  • Supported by:

    全军“十一五”计划课题(06MB236)。

PDF

516

Abstract:

BACKGROUND: Regulation of neural stem cells differentiation hampers its application, and the regulation mechanism remains poorly understood. Anterior subventricular zone (SVZa) is one of the rich zones of neural stem cells. The neural stem cells at SVZa can immigrate for a long distance with undifferentiated states and finally differentiate into interneurons at the olfactory bulbs. Bone morphogenetic protein-2 (BMP2) and DLX5 play a significant role in immigration and differentiation of neural stem cells at SVZa towards olfactory bulb.
OBJECTIVE: To study the feature of construction and immigration of neural stem cells at SVZa, and to review the role of BMP2 and DLX5 in neural stem cells differentiation, in addition, to explore the regulation mechanisms of neural stem cells differentiation.
METHODS: Literatures from PubMed database (http://www.ncbi.nlm.nih.gov/PubMed), CNKI database (www.cnki.net/index.htm) and WANFANG database (http://www.wanfangdata.com.cn) published between January 1997 and January 2009 were searched with the key words of “neural stem cells, SVZa, BMP2, and DLX5”. The repetitive and obsolete studies were excluded. 
RESULTS AND CONCLUSION: A total of 121 literatures were selected and primarily collected, including 86 Chinese literatures and 35 English literatures. Finally, according to standardization, 28 literatures were further analyzed. Neural stem cells of SVZa have unique construction and can immigrate for a long distance. BMP2 and DLX5 play a significant role in neuronal immigration and differentiation of the NSCs of SVZa, but the detailed mechanism of BMP2 and DLX5 in SVZa is not clear.

CLC Number: