Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (19): 3531-3533.doi: 10.3969/j.issn.1673-8225.2011.19.026

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The development of device for rotary three-dimensional cells culture 

Zhao Ling-xi1, Ding Hao1,2, Xu Meng1, Shang Kun2, Shen Li-xing1,2   

  1. 1Institute of Biomechanics and Rehabilitative Engineering, University of Shanghai for Science and Technology, Shanghai  200093, China
    2Shanghai Medical Instrumentation College, Shanghai 200093, China
  • Received:2010-11-28 Revised:2011-03-16 Online:2011-05-07 Published:2011-05-07
  • Contact: Ding Hao, Doctor, Associate professor, Master’s supervisor, Institute of Biomechanics and Rehabilitative Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Shanghai Medical Instrumentation College, Shanghai 200093, China dinghaoy@21cn.com
  • About author:Zhao Ling-xi★, Studying for master’s degree, Institute of Biomechanics and Rehabilitative Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China lingxi_zhao@126.com
  • Supported by:

    microinvasive Inspira tional Innovation Fund, Institute of Biomechanics and Rehabilitative Engineering, University of Shanghai for Science and Technology*

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Abstract:

BACKGROUND: It is widely used that vitro culturing endothelial cells to study atherosclerosis mechanism, and the key issues are if the monolayer endothelial cells could resist blood attack and how to achieve cells growth well-distributed.
The development of this device is aim to solve these problems.
OBJECTIVE: To develop a device that could supply a three-dimensional condition for cells to realize growth stick to elastic silicon chamber in order to improve growth uneven.
METHODS: It Weintroduced structure and functions of the device from controlled unit, mechanical unit and cells culture unit, and then used it to carry out an umbilical vein endothelial cells culture experiment.
RESULTS AND CONCLUSION: Rotary three-dimensional cells culture device could provide condition for cells metabolism and growth sticking to elastic silicon chamber well-distributed.

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