Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (18): 3243-3246.doi: 10.3969/j.issn.1673-8225.2011.18.004

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Steatotic liver in donor for living related liver transplantation

Cui Zi-lin1,2, Fu Zhi-ren1, Zhu Zhi-jun2, Zhang Ya-min2, Zhang Jian-jun2, Jiang Wen-tao2, Yang Tao2, Huai Ming-sheng2, Zhang Wei2   

  1. 1Department of Liver Transplantation, Changzheng Hospital, the Second Military Medical University of Chinese PLA, Shanghai  200003, China
    2Transplantation Department of Tianjin First Central Hospital, Tianjin  300192, China
  • Received:2010-11-05 Revised:2011-03-29 Online:2011-04-30 Published:2011-04-30
  • Contact: Fu Zhi-ren, Professor, Doctoral supervisor, Department of Liver Transplantation, Changzheng Hospital, the Second Military Medical University of Chinese PLA, Shanghai 200003, China
  • About author:Cui Zi-lin,☆ Doctor, Attending physician, Department of Liver Transplantation, Changzheng Hospital, the Second Military Medical University of Chinese PLA, Shanghai 200003, China; Transplantation Department of Tianjin First Central Hospital, Tianjin 300192, China gfaaron@126.com, cuizilin@medmai.com.cn
  • Supported by:

    China Medical Board in New York, No.06837*

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Abstract:

BACKGROUND: Steatotic liver graft transplantation affects donor safety as well as recipient survival in living related liver transplantation (LRLT).
OBJECTIVE: To assess safety of donors of steatotic liver and prognosis of steatotic liver grafts’ recipients in LRLT.
METHODS: We retrospectively reviewed 104 cases of LRLT, dividing them into 4 groups according to degree of macrovesicular fatty change upon intraoperative liver biopsy. The degree of macrovesicular steatosis was compared among four groups, and death cause was analyzed among 104 cases undergoing right liver transplantation.
RESULTS AND CONCLUSION: There was no statistically significant difference in postoperative hepatic function recovery of donors and recipients among four groups. Overall recipients’ prognosis was not different among the groups. No primary graft nonfunction (PNF) or delayed graft function (DGF) occurred. Mild macrovesicular steatotic livers may be good donor candidates without significant complications as long as sufficient residual liver volume is left for the donor. Mild macrovesicular steatotic graft did not increase the risk of graft dysfunction or morbidity in LRLT.

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