Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (39): 7312-7316.doi: 10.3969/j.issn.2095-4344.2012.39.020

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Three-dimensional finite element analysis and establishment of the lumbar spinal stenosis model in the rats

Dai Feng-lei, Liu Yi, Li Qin-liang, Chu Zhao-ming, Chen Jin-chuan, Wang Xi   

  1. Department of Spine Surgery, the Affiliated Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222000, Jiangsu Province, China
  • Received:2011-12-29 Revised:2012-01-10 Online:2012-09-23 Published:2012-09-23
  • Contact: Li Qin-liang, Master, Associate chief physician, Department of Spine Surgery, the Affiliated Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222000, Jiangsu Province, China liqinl@163.com
  • About author:Department of Spine Surgery, the Affiliated Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222000, Jiangsu Province, China

Abstract:

BACKGROUND: The establishments of lumbar spinal stenosis model are variable, and the results of spinal stenosis caused by silicone implant are similar to which caused by degeneration of the human body.
OBJECTIVE: To establish the lumbar spinal stenosis model using silicon chip to implant spinal canal in the rats, and to analyze the model through measuring the walking function and three-dimensional finite element.
METHODS: Thirty male Sprague Dawley rats were divided into two groups. Two pieces of silicone rubber were implanted into the lumbar (L4 and L5) epidural space to cause spinal stenosis in experimental group. Operation processes were the same in both groups, but silicone rubber was not implanted in the control group.
RESULTS AND CONCLUSION: In the experimental group, the postoperative running distance was significantly decreased as compared with the preoperation (P < 0.05), and the spinal was compressed about 50%-70%. The density of normal spinal canal was (32.4±19.58) Hu in the control group, while in the experimental group was (101.96±32.85) Hu. The results showed that the rat models of lumbar spinal stenosis are successfully established, and the making method is simple, effective and economical.

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