Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (44): 8186-8190.doi: 10.3969/j.issn.2095-4344.2012.44.004

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Effects of bone cement and tourniquet on coagulation function during total knee arthroplasty

Yin Jun-ping1, Miao Hai-min2, Qiao Guo-yong3, Yi Yan-li3   

  1. 1Department of Clinical Laboratory, General Hospital of Hanxing Administrative Bureau for Mining, Handan 056001, Hebei Province, China
    2Department of Infection, Handan Hospital of Traditional Chinese Medicine, Handan 056001, Hebei Province, China
    3Second Department of Orthopedics, Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei Province, China
  • Received:2012-07-02 Revised:2012-07-19 Online:2012-10-28 Published:2012-10-28
  • Contact: Qiao Guo-yong, Master, Associate chief physician, Second Department of Orthopedics, Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei Province, China qiaoguoyong@126.com
  • About author:Yin Jun-ping, Laboratorian-in- charge, Department of Clinical Laboratory, General Hospital of Hanxing Administrative Bureau for Mining, Handan 056001, Hebei Province, China qiaoguoyong@126.com

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Abstract:

BACKGROUND: Studies have shown that bone cement has a great effect on the patient's hemodynamic and blood coagulation during total knee arthroplasty.
OBJECTIVE: To observe the effects of bone cement and tourniquet on coagulation function during total knee arthroplasty.
METHODS: Forty osteoarthritis patients who underwent single total knee arthroplasty were randomly divided into two groups with randomized control study method: the application of tourniquet and patients who did not have tourniquet. The relative parameters were observed in all patients, including prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen and D-dipolymer. Coagulation function changes between two groups were compared.
RESULTS AND CONCLUSION: The prothrombin time was significantly decreased at 60 and 120 minutes after cement implantation (P < 0.05), and the levels of fibrinogen and D-dipolymer were increased after implantation in all patients (P < 0.05), especially in the patients who use of tourniquet. The changes vanished at 180 minutes after bone cement implantation. There was no significant difference in activated partial thromboplastin time and prothrombin time before and after bone cement implantation. The values of prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen and D-dipolymer were within the normal range. Compared with the patients who did not have tourniquet, the prothrombin time in the patients with tourniquet was shortened and the fibrinogen and D-dipolymer were increased (P < 0.05). The bone cement implantation can lead to temporal hypercoagulabale state during single total knee arthroplasty, and the tourniquet can aggravate the hypercoagulable state in patients.

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