Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (8): 1360-1364.doi: 10.3969/j.issn.1673-8225.2011.08.007

Previous Articles     Next Articles

Nano-hydroxyapatite/fibrin glue/recombinant human osteogenic protein-1 for repair of bone defects

Zhao Yu-chi1, Wang Da-ping2, Lai Yuan-wei1, Xiong Jian-yi2, Wang Li-gang1, Zhu Wei-min2, Huang Ren-hui1, Yuan Jie1   

  1. 1Shenzhen Yantian People’s Hospital, Shenzhen  518000, Guangdong Province, China
    2Shenzhen Second People’s Hospital, Shenzhen  518035, Guangdong Province, China
  • Received:2010-08-30 Revised:2011-01-01 Online:2011-02-19 Published:2011-02-19
  • Contact: Wang Da-ping, Chief physician, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong Province, China szhzwm@126.com
  • About author:Zhao Yu-chi, Professor, Master’s supervisor, Shenzhen Yantian People’s Hospital, Shenzhen 518000, Guangdong Province, China westerlife@126.com
  • Supported by:

    Shenzhen Science and Technology Research Project, No. 200533118*

PDF

447

Abstract:

BACKGROUND: The nano-hydroxyapatite/fibrin glue (Nano-HA/FG) is similar to the human tissues and possesses good biological and mechanical properties, but it lacks of bone induction effect.
OBJECTIVE: To investigate the repair capacity of nano-hydroxyapatite/fibrin glue/recombinant human osteogenic protein-1 (Nano-HA/FG/rhOP-1) on bone defects.
METHODS: Animal models of bone defects were established on the bilateral radius of New Zealand white rabbits, which were randomly divided into Nano-HA/FG/rhOP-1 artificial bone group (bone defect was repaired with artificial bone), Nano-HA/FG artificial bone group (bone defect was repaired with Nano-HA/FG artificial bone) and blank control group (bone defect was left unrepaired). The ability of repairing bone defect was evaluated by gross specimen observation, X-ray radiograph, scanning electronic microscope, radionuclide bone scan, and biomechanical test at 4, 8, 12 weeks after operation.
RESULTS AND CONCLUSION: Radiographical scores, osteogenic effect, aggregation intensity of radionuclide, and biomechanical strength in Nano-HA/FG/ rhOP-1 artificial bone group were higher than that in Nano-HA/FG group (P < 0.05) at 4, 8, 12 weeks after operation. There was no bone connection in the defect field, bone end sclerosis, and the bone defect was not repaired in the blank control group. It suggested that Nano-HA/FG/ rhOP-1 artificial bone has good repair capacity of bone defects and is expected to be an ideal repairing material for bone defect.

CLC Number: