Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (6): 1115-1118.doi: 10.3969/j.issn.1673-8225.2011.06.037

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Statins effects on endothelial progenitor cells

Ma Jun, Jiang Meng, He Ben   

  1. Department of Cardiology, Renji Hospital Affiliated to Medicine College, Shanghai Jiao Tong University, Shanghai  200001, China
  • Received:2010-09-27 Revised:2010-11-01 Online:2011-02-05 Published:2011-02-05
  • Contact: Jiang Meng, Doctor, Associate chief physician, Department of Cardiology, Renji Hospital Affiliated to Medicine College, Shanghai Jiao Tong University, Shanghai 200001, China jiangmeng0919@163.com; He Ben, Doctor, Chief physician, Department of Cardiology, Renji Hospital Affiliated to Medicine College, Shanghai Jiao Tong University, Shanghai 200001, China heben1025@126.com
  • About author:Ma Jun, Department of Cardiology, Renji Hospital Affiliated to Medicine College, Shanghai Jiao Tong University, Shanghai 200001, China majunhenry@hotmail.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30800453*; the Shanghai Rising-star Program, No. 10QA1404500*; the Undergraduate Student Innovation Activity Project of Shanghai City, No. IAP3117*; the “Yigong(Li) Crossing Research Foundation” of Shanghai Jiao Tong University, No. YG2010MS29*

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Abstract:

BACKGROUND: As the statins are widely used as clinical lipid-lowering drugs, and their different dosages and treatment periods may have short and long-term effects on endothelial progenitor cells (EPCs).
OBJECTIVE: To summarize the investigative situation and progression about the effects of statins on EPCs.
METHODS: We used the databases of China National Knowledge Infrastructure and Pubmed (1995-01/2009-11) to search relevant articles about EPCs and statins. “Endothelial progenitor cells”, “statins” were taken as key words and then selected some relevant articles. Articles in the same field published recently or in authoritative journals were included. There were 843 articles after the initial survey. Then 19 articles involving statins and EPCs were selected according to inclusion criteria.
RESULTS AND CONCLUSION: Statins have multiple effects on EPCs. In the short-term treatment with the low dosage of statins, statins show the protective effects on EPCs against cardiovascular disease, enhancing the function of all aspects of EPCs. The result of the long-term treatment with high-dosage of statins decreases the number of EPCs and inhibites angiogenesis, which reveals the research value for inhibiting tumor angiogenesis.

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