Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (6): 1107-1110.doi: 10.3969/j.issn.1673-8225.2011.06.035

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Feasibility of stem cells transplantation for the treatment of chronic renal disease

Zhou Jing1, 2, Pan Xing-hua1, Pang Rong-qing1, Cai Xue-min1   

  1. 1Center for Stem Cells and Tissue Engineering, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA, Kunming  650032, Yunnan Province, China
    2Institute of Clinical Medicine, Kunming Medical College, Kunming  650031, Yunnan Province, China
  • Received:2010-08-28 Revised:2010-12-18 Online:2011-02-05 Published:2011-02-05
  • Contact: Correspondence to: Pan Xing-hua, Doctor, Chief physician, Center for Stem Cells and Tissue Engineering, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA, Kunming 650032, Yunnan Province, China xinghuapan@yahoo.com.cn
  • About author:Zhou Jing★, Studying for master’s degree, Physician, Center for Stem Cells and Tissue Engineering, Kunming General Hospital of Chengdu Military Area Command of Chinese PLA, Kunming 650032, Yunnan Province, China; Institute of Clinical Medicine, Kunming Medical College, Kunming 650031, Yunnan Province, China zhoujwl@163.com
  • Supported by:

    Major Program of Natural Science Foundation of Yunnan Province, No. 2003M0013Z*

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Abstract:

BACKGROUND: The incidence of chronic renal disease was an increasing trend year by year; the traditional hemodialysis and allograft renal transplantation are is still the only treatment option. With the development of stem cell-based regenerative medicine research, it is possible to find the ideal treatment of chronic renal disease from the perspective of stem cells.
OBJECTIVE: To review action mechanism and the possibility of clinical application in the treatment of chronic renal disease from different sources of stem cells.
METHODS: Articles addressing stem cells for the treatment of chronic renal disease were retrieved by computer in CNKI database and PubMed database from January 2006 to December 2009 with the key words of “embryonic stem cells, bone marrow stem cells, induced pluripotent stem cells, chronic kidney disease” in Chinese or “embryonic stem cells, bone marrow stem cells, induced pluripotent stem cells, chronic kidney disease” in English in the title and abstract. The articles which contents are related to stem cell for the treatment of chronic renal disease were selected. The articles which published in recently literatures or the authoritative magazines were selected in the same field. A total of 128 literatures were obtained from the computer screen, and 30 documents of them were involved for summarization according to the inclusion criteria.
RESULTS AND CONCLUSION: Multiple sources of stem cells have the potential to differentiate to renal histiocyte. A large numbers of experimental studies have shown that stem cells transplantation on acute kidney injury repair has a positive effect. At the same time, studies for the treatment of renal fibrotic diseases and end stage renal disease have reported. Through the description of characteristics of stem cells and related mechanisms of stem cells for the treatment of renal disease, We hope there will be a new approach to the treatment of chronic renal disease.

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