Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (42): 7959-7962.doi: 10.3969/j.issn.1673-8225.2010.42.041

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Comparison of sodium alginate microspheres and gelatin sponge embolization for massive hemoptysis due to pulmonary tuberculosis in 143 cases

Huang Qin, Tian Yuan, Ao Guo-kun, Tan Zhi-yuan, Liu Jie-ai   

  1. Department of Radiology, The 309 Hospital of Chinese PLA, Beijing   100091, China
  • Online:2010-10-15 Published:2010-10-15
  • Contact: Ao Guo-kun, Master, Associate chief physician, Department of Radiology, The 309 Hospital of Chinese PLA, Beijing 100091, China
  • About author:Huang Qin, Technician-in-charge, Department of Radiology, The 309 Hospital of Chinese PLA, Beijing 100091, China sjk1992@sohu.com

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Abstract:

BACKGROUND: Among many treatment programs for massive hemoptysis due to pulmonary tuberculosis, the efficacy of embolization is most clear and obvious. There are a variety of plug blocking materials, such as traditional gelatin sponge, polyvinyl alcohol particles, widely used coil, sodium alginate microspheres embolic agent and so on. They have different efficacies.
OBJECTIVE: To compare the therapeutic effect of sodium alginate microspheres versus gelatin sponge embolization of bronchial artery for massive hemoptysis due to pulmonary tuberculosis.
METHODS: Totally 143 cases of massive hemoptysis due to pulmonary tuberculosis were divided into two groups according to different embolic materials, a gelatin group and a sodium alginate microsphere group. Selective bronchial artery angiography was performed first, superselective bronchial arterial cannulation was done, and finally embolic materials were into the distal bronchial artery for embolization.
RESULTS AND CONCLUSION: In gelatin group, 92 target vessels showed a thrombosis, 44 patients (58.7%) were immediately stopped bleeding after embolization, total effective rate was 81.3%. In 2-year follow-ups, 12 cases (25.3%) recurred. In sodium alginate microsphere group, 83 target vessels showed a thrombosis, and 60 patients (89.1%) were immediately stopped bleeding after embolization, total effective rate was 92.6%. In 2-year follow-ups, 5 cases (7.8%) recurred. The immediate hemostatic effect in the sodium alginate microsphere group was significantly better than that of gelatin group (P < 0.05), the cure rate was significantly higher than gelatin group (P < 0.05); the recurrence rate was significantly lower than gelatin group (P < 0.05); total effective rate was significantly higher than gelatin group (P < 0.05). There was no significant difference between two groups regarding the incidence of complications (P > 0.05). The sodium alginate microsphere for bronchial artery embolization is safe and effective to treat for massive hemoptysis due to pulmonary tuberculosis, with low recurrence rate, thus worthy of clinical application.

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