Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (42): 7966-7970.doi: 10.3969/j.issn.1673-8225.2010.42.043

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Biocompatibility of a magnesium-zinc alloy implanted in rat cecum

Yuan Qing-ling1, Yan Jun1, Zheng Qi1, Zhang Shao-xiang2, Zhang Xiao-nong2   

  1. 1 Department of General Surgery, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai  200233, China; 2 School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai  200240, China
  • Online:2010-10-15 Published:2010-10-15
  • Contact: Zheng Qi, Professor, Chief physician, Doctoral supervisor, Department of General Surgery, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China zhengqi1957@hotmail.com
  • About author:Yuan Qing-ling★, Studying for master’s degree, Department of General Surgery, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China yuanqingling113@sina.com
  • Supported by:

     the National Natural Science Foundation of China, No. 30901422*

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Abstract:

BACKGROUND: Magnesium alloy studies in orthopedic field have been carried out, and good biocompatibility has been reported. However magnesium alloys have not yet been researched in the intestine.
OBJECTIVE: The biodegradable magnesium-zinc alloy samples are implanted around the rat cecum to investigate the biocompatibility in rat.
METHODS: Sprague Dawley rats were randomly divided into magnesium alloy group, medical titanium group and the sham-operated group. Then magnesium-zinc alloy samples with the dimension of 5 mm × 1 mm × 1 mm were embedded in the cecum incision in the magnesium alloy group. The medical titanium was embedded in the medical titanium group, and just suture in the sham-operated group. Prior to surgery and at 7, 14, 21 and 28 days after operation, the serum glutamic-oxaloacetic transaminase, creatinine and magnesium ion concentration were examined in each group. X-ray film on implanted region. The pathological changes in liver, kidney and cecum were examined.
RESULTS AND CONCLUSION: There were no significant differences in serum glutamic-oxaloacetic transaminase, creatinine and magnesium ion concentrations among each group (P > 0.05). Magnesium-zinc alloy degraded gradually during 28 days. The pathology of liver, kidney and cecum was normal. Results suggested that magnesium-zinc alloy had no obvious effect on the cecum. The degradation time to play a fixed function of time was longer than the intestinal healing time, with good biocompatibility. Magnesium-zinc alloy can be used as anastomotic nail for stomach intestine anastomat.

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