Abstract:

BACKGROUND: At present, infection following transplantation is the greatest risk for recipients. With increasing development of organ transplantation, organ source is insufficient, and a large number of marginal donor organs have been used. Some infectious diseases are propagated to the recipients during transplantation, including some orphan diseases. In 2009, the assessment standards for donor-derived disease transmission were formulated by OPTN/UNOS Disease Transmission Advisory Committee, which provides uniform standards for the diagnosis of donor-derived disease transmission.
OBJECTIVE: To summarize the literatures of donor-derived infections of solid organ transplantation recipients.
METHODS: A computer-based online search of Pubmed database, Chinese Biomedical Literature Database, CNKI Database and Wanfang Database was performed to search articles related to donor-derived disease transmission published from January 2000 to January 2010 with the key words “transmission, organ transplantation” in English, and “organ transplantation, donor, transmission” in Chinese. According to references of collected literature, some studies of other diseases were included. Articles involving tissue transplantation, repetitive or outdated contents were excluded.
RESULTS AND CONCLUSION: Finally, 48 articles were included. In the last decade, the case reports of donor-derived infections of solid organ transplantation recipients involved in the transmission of infections of bacteria, virus and parasite, most of them were about the infections of rare pathogen. For the incidence of the donor-derived infections, donor inclusive and exclusive criteria become important. However, the incidence of donor-derived infections is low, which would not hold-back the progress of organ transplantation.