Abstract:

BACKGROUND: The most significant factor that affects the life span of joint prosthesis is the artificial joint aseptic loosening.
OBJECTIVE: To explore the early diagnosis of artificial joint aseptic loosening methods in order to facilitate active early treatment.
METHODS: A computer-based online search of PubMed database, CNKI database, VIP database and Wanfang database between May 1997 and October 2010 was performed to search related articles with the key words of “aseptic loosening, artificial joint, prosthesis, osteolysis, early diagnosis” in English or Chinese. Literatures related to aseptic loosening of prosthesis were selected; in the same field, the articles published lately in authoritative journals were preferred. A total of 182 literatures were primarily selected, and 39 documents of which addressing the analysis and treatment of aseptic loosening of prosthesis were involved for summary according to inclusion criteria.
RESULTS AND CONCLUSION: Aseptic loosening of prosthesis and osteolysis has a close relationship with abnormality of bone metabolism and inflammatory reaction. Therefore, related cytokines of inflammatory reaction induced by bone metabolic markers and wear particles can be used for early diagnosis. Isotopic tracer can not only displays the morphology of tissue and organ, but also reflects the function of tissues and organs by showing physiological and biochemical processes of organs or tissues. Pathological changes can be found earlier than imaging for a few weeks or even months.