Abstract:

OBJECTIVE: To describe the clinical application of several important carrier materials.
METHODS: Using “drug carrier, sustained-release materials, biodegradable” in Chinese as the key words, China Academic Journal Full-text database (CNKI: 1989/2010) was retrieved online for all relevant literatures. Meta analysis and repeated studies were excluded, and ultimately 20 articles were involved in the final analysis.
RESULTS: The biodegradable synthetic polymer materials are safe and reliable, they have good biocompatibility and become a preferred material of drug delivery carriers; as a drug delivery carrier, chitosan plays an important role on reducing delivery times, reducing drug toxicity, and improving drug effect; nanofiber carriers could remarkably enhance the sustained-release of the drugs; fiber protein exhibits good biocompatibility and considered as a good carrier for drug delivery.
CONCLUSION: The drug controlled-release system shows many advantages in vivo, such as passive targeting and sustained-release, it is an important component of drug delivery system and the main factors influencing the efficacy.