Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (3): 453-456.doi: 10.3969/j.issn.1673-8225.2011.03.018

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In vitro antibacterial test of the surface antibacterial coating of a new nano-silver/polyurethane biliary stent

He Wei, Wang Xiang, Gao Ying, Liang Jun-cai, Yu Ting-ting, Fan Zhi-ning   

  1. Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing   210011, Jiangsu Province, China
  • Received:2010-07-09 Revised:2010-08-13 Online:2011-01-15 Published:2011-01-15
  • Contact: Fan Zhi-ning, Chief physician, Doctoral supervisor, Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China fanzhining@hotmail.com
  • About author:He Wei★, Studying for master’s degree, Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China bingbing_he@yeah.net
  • Supported by:

     the National High-Tech Research and Development Projects of China (863 Project), No. 2007AA02190*

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Abstract:

BACKGROUND: Biliary stents have been widely used in a variety of benign and malignant bile duct stricture as a palliative treatment. Its short-term efficacy is significant, but long-term use is limited by stent restenosis. 
OBJECTIVE: To produce a new antibacterial coating used in biliary stent by means of nano-silver/polyurethane, and to test in vitro antibacterial properties.
METHODS: Firstly, composite materials were made of nano-silver and polyurethane by in situ reduction method. Antibacterial test was used to detect in vitro antibacterial properties against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterococci of three groups: experimental group (nano-silver/polyurethane), positive control group (filter paper soaked in silver nitrate solution) and negative control group (polyurethane), antibacterial zone diameters were measured and analyzed.
RESULTS AND CONCLUSION: The difference was not significant between experimental group and positive control group in the antibacterial effect on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterococci. Nano-silver/polyurethane composite has good antibacterial property and better stability.

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