METHODS: The GYROID structure was selected in the Rhinoceros 7 software with the single cell size of 6 mm and the wall thickness of 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 mm. The mechanical properties of the GYROID structure were analyzed by finite element method. 3D printing of GYROID structural test specimens with different wall thickness (0.2, 0.3, 0.4, 0.5, 0.6, 0.7, and 0.8 mm) was performed to test the mechanical properties of the specimens through room temperature compression experiments. A wall thickness value conforming to the range of mandibular mechanical properties was selected through finite element analysis and room temperature compression test results. An adult male mandibular CT data were used for inverse modeling to design a condylar prosthesis with an internal GYROID. Finite element analysis was used to simulate the movement of the apical staggered position and the opposite-blade jaw position after condylar prosthesis replacement.
RESULTS AND CONCLUSION: (1) The results of finite element analysis and room temperature compression experiment showed that the elastic modulus of the GYROID structure increased with the increase of wall thickness. The elastic modulus of the GYROID structure with wall thickness of 0.5-0.7 mm was within the range of the elastic modulus of the mandible (1.5-4.0 GPa). Therefore, the 6 mm monocellular GYROID structural model with a wall thickness of 0.6 mm was selected for the design of the condylar prosthesis. (2) The results of finite element analysis showed that the stress distribution of mandibular model was symmetrical. The stress distribution of the two types of occlusion was roughly the same, and the stress peak was not significantly different. The stress concentrated in the neck of the condylar prosthesis, and the stress on the replacement side was slightly larger than that on the healthy side. The maximum equivalent stress of the whole internal fixation model was 269.34 MPa, and the maximum equivalent stress of the screw was 20.14 MPa. The equivalent stress and equivalent strain values of the prosthesis were greater than that of the opposite edge jaw position when the tooth tip was interlaced. The equivalent stress and equivalent strain values of the screw were smaller than that of the opposite edge jaw position when the tooth tip was interlaced. (3) The results showed that the design and retention of the personalized GYROID condylar prosthesis were good, which was consistent with the mechanical conduction of the mandible.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程