Low-frequency pulsed magnetic field induces classical transient receptor potential channels 1 to relieve lower limb muscle weakness in patients recovering from COVID-19

doi:10.12307/2024.281

Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (16): 2605-2612.doi: 10.12307/2024.281

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Low-frequency pulsed magnetic field induces classical transient receptor potential channels 1 to relieve lower limb muscle weakness in patients recovering from COVID-19

Li Zhongshan1, 2, Bao Yijun3, Liu Jie4, Kong Weiqian5, Li Wei5, Chen Lin6, Bai Shi5, 7, Yang Tieli8, Wang Chunlu9

1College of Sports Science, Fujian Normal University, Fuzhou 350117, Fujian Province, China; 2Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China; 3The Fourth Affiliated Hospital of China Medical University, Shenyang 110044, Liaoning Province, China; 4Experimental Research Center, China Medical University, Shenyang 110122, Liaoning Province, China; 5College of Information Science and Engineering, Shenyang University of Technology, Shenyang 111003, Liaoning Province, China; 6College of Life Science and Health, Northeastern University, Shenyang 110167, Liaoning Province, China; 7Magnetic Medical Detection and Treatment Innovation Center of Liaoning Province, Shenyang 110034, Liaoning Province, China; 8Capital University of Physical Education and Sports, Beijing 100191, China; 9College of Ice Sports, Beijing Sport University, Beijing 100084, China

Received:2023-03-15 Accepted:2023-04-01 Online:2024-06-08 Published:2023-07-31
Contact: Bai Shi, College of Information Science and Engineering, Shenyang University of Technology, Shenyang 111003, Liaoning Province, China; Magnetic Medical Detection and Treatment Innovation Center of Liaoning Province, Shenyang 110034, Liaoning Province, China Yang Tieli, Capital University of Physical Education and Sports, Beijing 100191, China Wang Chunlu, College of Ice Sports, Beijing Sport University, Beijing 100084, China
About author:Li Zhongshan, PhD candidate, College of Sports Science, Fujian Normal University, Fuzhou 350117, Fujian Province, China; Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China
Supported by:
the National Natural Science Foundation of China (Youth Program), No. 62001313 (to BS); General Project of Federation of University Sports of China, No. L202103003 (to LZS)

Abstract

Abstract: BACKGROUND: Muscle weakness is a common symptom after coronavirus disease 2019 (COVID-19) infection and affects the ability to perform daily activities in humans during recovery. Low-frequency pulsed magnetic field stimulation at a strength of 1.5 mT and a frequency of 3 300 Hz can enhance the maximal voluntary contraction and strength endurance of human skeletal muscle by inducing and activating classical transient receptor potential channel 1 (TRPC1), which produces a series of pathological support effects on muscle tissue. It has not been studied whether this means will improve muscle weakness in patients recovering from COVID-19.
OBJECTIVE: To select the low-frequency pulsed magnetic field for magnetic stimulation of lower limb muscle groups in patients with COVID-19, in order to observe the effect of this stimulation on the improvement of muscle weakness of lower limb muscle groups in patients with COVID-19 during the recovery period.
METHODS: Fourteen patients infected with COVID-19 (Omicron strain) positive for Innovita COVID-19 Ab Test (Colloidal Gold) and accompanied by muscle weakness were recruited and randomly divided into two groups: a test group receiving magnetic field stimulation and a control group receiving sham treatment, respectively. The total duration of the trial was 3 weeks. The test group was given low-frequency pulsed magnetic stimulation of the lower limbs every 48 hours and the control group was given the same intervention procedure as the test group but with sham stimulation. Patients in both groups were not informed whether the magnetic stimulation apparatus was running or not. Nine sessions were performed in both groups and the changes in the maximum voluntary contraction, explosive leg force and strength endurance of the local muscle groups of the lower limbs were subsequently observed in both groups.
RESULTS AND CONCLUSION: Among the eight local muscle groups collected, seven local muscle groups in the test group showed an increase in the maximum voluntary contraction value after 3 weeks of low-frequency pulsed magnetic field stimulation. In the control group, there were only three muscle groups with improvement in the maximum voluntary contraction. The rate of improvement in the anterior and posterior muscle groups of the left leg in the test group was significantly higher than that in the control group. The longitudinal jump height and peak angular velocity of the knee joint in both groups were improved compared with the pre-test measurement, and the elevation rate of jumping height in the test group was higher than that in the control group. Under the fatigue condition, the decline rates of peak angular velocity of the knee joint and jumping height in the test group decreased significantly, while those in the control group did not change significantly. The above data confirmed that the low-frequency pulsed magnetic field stimulation with the intensity of 1.5 mT and frequency of 3 300 Hz could improve the muscle strength of more local muscle groups in the lower limbs of patients with COVID-19 during the recovery period compared with the human self-healing process, and the whole-body coordination ability and functional status based on explosive leg force of the legs could be significantly improved. Therefore, low-frequency pulsed magnetic field stimulation can be used as an effective, non-exercise rehabilitation tool to improve muscle weakness in the lower limbs of patients with COVID-19.

Key words: novel coronavirus, COVID-19, novel coronavirus pneumonia, pulsed magnetic field, classical transient receptor potential channel 1, TRPC1, muscle weakness

CLC Number:

Li Zhongshan, Bao Yijun, Liu Jie, Kong Weiqian, Li Wei, Chen Lin, Bai Shi, Yang Tieli, Wang Chunlu. Low-frequency pulsed magnetic field induces classical transient receptor potential channels 1 to relieve lower limb muscle weakness in patients recovering from COVID-19[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(16): 2605-2612.

Figures/Tables 10

References

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Low-frequency pulsed magnetic field induces classical transient receptor potential channels 1 to relieve lower limb muscle weakness in patients recovering from COVID-19

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