Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (30): 5569-5576.doi: 10.3969/j.issn.2095-4344.2012.30.013

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Effect of bone targeted affinity medicinal guiding in preventing and treating primary osteoporosis

Wu Mi-shan1, Wu Bo-wen2, Ren Li-zhong3, Wang Ru1, Bai Xia1, Han Hong-wei1, Li Bin4, Zhao Su-zhi5   

  1. 1Department of Pharmacology of Traditional Chinese Medical Formulae, Traditional Chinese Medicine College of Hebei Medical University, Shijiazhuang 050091, Hebei Province, China;
    2Department of Clinical Medicine (Grade 2011), Western Hills Campus of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China;
    3Department of Orthopedics, the First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China;
    4Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China;
    5Qiaodong District Hospital of Shijiazhuang, Shijiazhuang 050041, Hebei Province, China
  • Received:2012-01-05 Revised:2012-02-12 Online:2012-07-22 Published:2012-07-22
  • Contact: Zhao Su-zhi, Associate chief physician, Qiaodong District Hospital of Shijiazhuang, Shijiazhuang 050041, Hebei Province, China okgood888@163.com
  • About author:Wu Mi-shan☆, Doctor, Professor, Master’s supervisor, Department of Pharmacology of Traditional Chinese Medical Formulae, Traditional Chinese Medicine College of Hebei Medical University, Shijiazhuang 050091, Hebei Province, China wumishan@163.com

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Abstract:

BACKGROUND: The theory of “kidney is in charge of the bones” is in line with the mechanism of bone metabolic regulation in modern medicine, the tonifying kidney prescriptions made according to the bone targeted affinity and medicinal guiding of cell signal transduction has effective action for osteoporosis, but further researches should focus on the action mechanism of the compatibility ratio of high dose and low dose guiding drugs at skeleton formation. It can clarify the two arguments about application of high dose and low dose guiding drugs by observing osteoporosis relevant specific indexes in clinic.
OBJECTIVE: To investigate the correlation between target-oriented administration and drug own selectivity target-tropism special guiding carrier structure by comparing the treatment effects of the channel tropism functions of prescription for kidney tonifying of the compatibility ratio of high dose and low dose guiding drugs on primary osteoporosis of the channel and collaterals according to diagnosis.
METHODS: The 180 patients with osteoporosis were randomly divided into six groups: high dose guiding drugs for kidney meridian group (HKG), low dose guiding drugs for kidney meridian group (LKG), high dose guiding drugs for liver meridian group (HLG), low dose guiding drugs for liver meridian group (LLG), high dose guiding drugs for spleen meridian group (HSG), low dose guiding drugs for spleen meridian group (LSG) with 30 cases in each group. Patients in HKG, HLG and HSG were given 20 g Achyranthes bidentata Bl versus 10 g Kang Gu Song Dan Qi instant granules every time respectively, three times daily for successive 6 months. Patients in LKG, LLG and LSG were given 20 g Achyranthes bidentata Bl versus 10 g Kang Gu Song Dan Qi instant granules every time, three times daily, six months as one course of treatment, and no other anti-osteoporosis treatment was performed during administration. The curative effect was evaluated by observing bone ache symptoms and changes in bone mineral density of lumbar vertebrae, serum calcium, alkaline phosphatase, bone gla protein, urinary hydroxyproline, urine calcium, urine creatinine, estradiol and testosterone.
RESULTS AND CONCLUSION: High dose guiding drugs versus Kang Gu Song Dan Qi instant granules could treat primary osteoporosis of the channel and collaterals according to diagnosis. It could obviously increase the bone mineral density of lumbar vertebrae and the alleviating rate of ostealgia, and without any related adverse effect. Prescription for tonifying kidney of the compatibility ratio of high dose and low dose guiding drugs has effects on treating the primary osteoporosis, and the effect of the former is better than the latter.

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