Association of serum vitamin D with bone mineral density of middle-aged and elderly patients in southern China

doi:10.3969/j.issn.2095-4344.2017.28.004

Abstract

Abstract:

BACKGROUND: Vitamin D is a key substance that promotes calcium absorption and maintains the health of skeletal system, but its relationship with bone mineral density remains controversial.
OBJECTIVE: To determine the relationship between serum level of vitamin D and bone mineral density in the middle-aged and elderly patients in southern China.
METHODS: The patients aged over 50 years old admitted in the clinic and in-patient department of a large-scale 3A hospital from July 2014 to December 2016 were enrolled and the clinical data were collected. Then, the association between the serum level of 25-hydroxy vitamin D (25(OH)D) and bone mineral density (at the lumbar spine, femoral neck and total hip) was analyzed.
RESULTS AND CONCLUSION: A total of 1 154 patients (77.2% female) were enrolled with a mean age of (64.62±10.48) years, and the mean serum level of 25(OH)D was (62.07±37.40) nmol/L. The serum level of 25(OH)D decreased with age increasing, and the proportion of vitamin D insufficiency/deficiency in patients aged 50-59, 60-69 and ≥ 70 years old was 71.3%, 77.0% and 80.1%, respectively. Correlation analysis showed that the serum level of 25(OH)D was not associated with bone mineral density at the lumbar spine, but had a weakly positive correlation with bone mineral density at the femoral neck and total hip (r=0.09 and 0.08, P < 0.01). For patients with vitamin deficiency (25(OH)D ≤ 50 nmol/L), there was a significantly positive correlation between serum level of vitamin D and bone minerat density at the lumbar spine, femoral neck and total hip (r =0.117, 0.120 and 0.146, P < 0.01). After subgroup analysis, vitamin D level was not associated with bone mineral density in male, but was significantly associated with that in female (r=0.105, 0.135 and 0.171 for the lumbar spine, femoral neck and total hip, respectively, P < 0.01). Therefore, the prevalence of vitamin D deficiency is common in middle-aged and elderly patients in southern China. The serum level of vitamin D is not related to bone mineral density in male, but was positively correlated with that in female.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Vitamin D, Bone Density, Bone Diseases, Metabolic, Osteoporosis

CLC Number:

R318

Zhang Liang-ming, Yang Yang, Chen Zhen-xiang, He Tian-wei, He Lei, Liu Bin, Rong Li-min. Association of serum vitamin D with bone mineral density of middle-aged and elderly patients in southern China[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(28): 4448-4453.

Figures/Tables 3

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