Biocompatibility of hirudin peptide-modified acrylic intraocular lens

doi:10.3969/j.issn.2095-4344.2016.21.016

Abstract

Abstract:

BACKGROUND: Because of poor biocompatibility, conventional intraocular lenses (IOLs) used to improve visual acuity can result in a higher incidence of inflammatory foreign body reactions.

OBJECTIVE: To study the biocompatibility and therapeutic effects of hirudin peptide-modified acrylic IOL on eye diseases.

METHODS: By immersion coating method, we prepared a polymethylmethacrylate IOL by the modification with hirudin polypeptides and observed its biocompatibility through the cytological observation. In this study, six New Zealand white rabbits were equivalently randomized into conventional and hirudin peptide grouppolypeptide hirudin group. Rabbits in the conventional group were given conventional lens implantation; while those in the hirudin peptide group underwent hirudin peptide-modified polymethylmethacrylate IOL.

RESULTS AND CONCLUSION: Three days after implantation of hirudin peptide-modified polymethylmethacrylate IOL, cells proliferated and spread well on the acrylic IOL, but on the cell membrane, there were a few cells most of which were gathered spherically with no spreading. In the hirudin peptide group, some cells attached to the border zone migrated to the IOL surface, but did not impede the central visual field; in the conventional group, the IOL surface was still covered by fibrotic cell membrane. Compared with the conventional group, the score in the Schirmer I test was increased but the breakup time of tear film decreased in the hirudin peptide group. To conclude, the polymethylmethacrylate IOL modified by hirudin peptides has good physicochemical properties and biocompatibility, increases visual acuity, and yields satisfactory outcomes in the cataract treatment, which provides a new insight into the treatment of cataract.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Cataract, Inflammation, Phakic Intraocular Lenses, Tissue Ergineering

CLC Number:

R318

Li Su-hua, Zhang Yi-ni, Li Jian-bo. Biocompatibility of hirudin peptide-modified acrylic intraocular lens[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(21): 3150-3155.

Figures/Tables 4

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