Ways for establishing a rat model of spinal cord contusion: a network meta-analysis

doi:10.3969/j.issn.2095-4344.2016.18.022

Abstract

Abstract:

BACKGROUND: Animal experimental study on spinal cord injury used injury mode and similarity of clinical spinal cord injury as an important reference index of selecting modeling approach.

OBJECTIVE: To compare the difference among the use of precision impactor, homemade Allen’s impactor, spinal cord compression method and clamping method in rat models of spinal cord injury, and to provide a new basis for the selection of the modeling method of a rat model.

METHODS: PubMed, CNKI, Wanfang and VIP databases were retrieved with computer from Building to June 20, 2015. Eligible literatures were included and analyzed by ADDIS software.

RESULTS AND CONCLUSION: A total of 26 studies met inclusion criteria, containing 599 rats. After analysis of the inclusion studies, the model could be effectively made in each modeling method. The modeling method with effects from best to poor is as follows in order: precision impactor, clamping method, homemade Allen’s impactor and spinal cord compression method. According to the lowest mortality, there were precision impactor, homemade Allen’s impactor and clamping method. From the point of view of function and mortality, the use of precision impactor is the best. The use of homemade Allen’s impactor is the most economical. The clamp method could achieve a balance between them.
中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Spinal Cord Injuries, Models, Animal, Evidence-Based Medicine, Tissue Engineering

Li Bo-lin, Zhou Bin-bin, Jin Xin, Yang Cheng-cheng. Ways for establishing a rat model of spinal cord contusion: a network meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(18): 2731-2736.

Figures/Tables 5

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