OBJECTIVE: To understand physiological, biochemical and pathological changes of animal bodies after high-energy vibration-induced injury.

METHODS: A total of 32 dogs were randomly divided into four groups. Dogs in the mild vibration injury group, moderate vibration injury group and severe vibration injury group received 700, 1 000, and 2 100 m/s² vibration. Dogs in the control group were considered as normal controls. Within 14 days after vibration, serum K⁺, Ca²⁺, Zn²⁺, S100β, and neuron specific enolase concentrations were detected. Immunohistochemical staining was observed in the spinal cord and the brain. RESULTS AND CONCLUSION: Serum K⁺, Ca²⁺, Zn²⁺ concentrations showed a regular change in the three vibration injury group, and no evident change was found immediately after vibration injury. K⁺ concentrations reached a minimum at 0.5 day after vibration injury. Ca²⁺ concentrations reached a minimum at 1 day after vibration injury. Zn²⁺ concentrations reached a minimum at 0.5 or 1 day. Above concentrations gradually increased and became normal at 14 days. Serum neuron specific enolase and S100β expression increased at 0.5 day after vibration in the three vibration injury groups, peaked at 1 day, gradually diminished, and recovered to a normal level or higher level at 14 days. In the three vibration groups, bleeding point of contact position and hedge position could be found in the spinal cord and brain. The degree of bleeding was more significant when killed instantly after vibration compared with that at 14 days. S100β, glial fibrillary acidic protein and neuron specific enolase expression increased in the spinal cord and brain.
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