Metabolomics characteristics in a rat model of myocardial infarction based on bibiometrics analyses

doi:10.3969/j.issn.2095-4344.2017.04.024

Abstract

Abstract:

BACKGROUND: Metabonomics has been proved to analyze and observe the pathological process of rat myocardial infarction and the underlying mechanism.
Abstract
OBJECTIVE: To further analyze the metabolomic pathways of bioinformatics in rat models of myocardial infarction.
METHODS: The experimental studies about rat myocardial infarction were retrieved from CNKI, WanFang, CqVip, PubMed and Embase databases. The metabolic products described in the literatures were collected and summarized. Signaling pathways were analyzed using KEGG database molecular function annotation, the enzymes, translocators and their properties were analyzed by HMDB database. Metabolites pathway were visualized with MetPA.
RESULTS AND CONSLUSION: A total of 26 metabolic products were identified in the included literatures and mainly participated in 29 metabolic pathways. Through topology analysis, 5 of the 10 metabolic pathways were selected and regarded as the metabolic pathways of myocardial infarction in rats, including aminoacyl-tRNA biosynthesis; glycine, serine and threonine metabolism; valine, leucine and isoleucine biosynthesis; biosynthesis of unsaturated fatty acids; phenylalanine, tyrosine and tryptophan biosynthesis. In conclusion, the bioinformatics analysis of metabolites in rats with myocardial infarction show that myocardial infarction is related to the metabolism and metabolic pathways of carbohydrates, proteins, fat and RNA.
Subject headings: Myocardial Infarction; Metabolome; Computational Biology; Tissue Engineering

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

CLC Number:

R318

Wu Xin-cheng1, Zheng Jing-hui2, Ma Xiao-cong1, Zhuo Xiao-yuan1, Zhang Xin-chun1. Metabolomics characteristics in a rat model of myocardial infarction based on bibiometrics analyses[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(4): 633-640.

Figures/Tables 5

References

[1] 向丽.麝香保心丸及组分配伍代谢组学研究[D].上海:第二军医大学,2009.

[2] 谭光国.中药四逆汤化学物质组和代谢组学研究[D].上海:第二军医大学,2012.

[3] 姜鹏.麝香保心丸代谢组学和代谢动力学研究[D].上海:第二军医大学,2012.

[4] 金文敏,穆殿平.芪参益气滴丸用于大鼠急性心肌梗死的代谢组学研究[J].天津药学,2015,27(6):9-13.

[5] 王静.复方中药芪参益气滴丸化学物质基础与作用机理研究[D].天津:南开大学,2011:1-127.

[6] 简维雄,黄献平,陈清华,等.基于气相色谱-质谱的大鼠心血瘀阻证血浆代谢组学研究[J].中国中西医结合杂志,2009,27(4): 796-798.

[7] 汪晋,张玉峰,邵青,等.三七总皂苷对急性心肌缺血大鼠血清代谢物组的影响研究[J].中国中药杂志,2010,35(23):3199-3202.

[8] Liu YT,Jia HM,Chang X,et al.The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics.Mol. BioSyst.2013;9(11): 2823-2834.

[9] Liu YT,Jia HM,Chang X,et al. Metabolic pathways involved in Xin-Ke-Shu protecting against myocardial infarction in rats using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry .J Pharm Biomed Anal.2013;5 (90): 35-44.

[10] 董志欢,李彤,张磊,等.大鼠急性心肌梗死后期血清代谢轮廓研究[J].天津医药,2015,43(10):1166-1170.

[11] 吴德坤,郑景辉,王铁华,等.大鼠急性心肌梗死血瘀证心肌组织代谢组学的生物信息学分析[J].辽宁中医杂志,2016,43(3): 630-632.

[12] 李伟霞.当归-川芎药对功效物质与配伍作用机理研究[D].南京:南京中医药大学,2014.

[13] 郑景辉,陈建军,简维雄,等.冠心病心血瘀阻证患者血浆代谢组学的通路分析[J]. 时珍国医国药,2015,26(2): 485–487.

[14] 张玲.基于LC-Q/TOF-MS生当归及其不同炮制品挥发油干预LPS炎症大鼠的代谢组学研究[D].甘肃: 甘肃农业大学,2015.

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