Effects of 60Co irradiation and trace element zinc on fixation strengths of titanium implant

doi:10.3969/j.issn.2095-4344.2016.25.018

Abstract

Abstract:

BACKGROUND: Irradiation therapy in the cancer patients after surgery may have negative effects on implant fixation.

OBJECTIVE: To observe the effects of ⁶⁰Co irradiation and trace element zinc on fixation strengths of titanium implant.

METHODS: Thirty-six adult male rabbits were involved. One piece of titanium implant was separately placed into the bilateral proximal tibial heads in rabbits to set up animal models of titanium implants. The animals were randomly divided into control group, zinc supplement group,⁶⁰Co irradiation group and ⁶⁰Co irradiation and zinc supplement group. Zinc sulfate of 10 g/L was administered intramuscularly to animals in the zinc supplement group at the dose of 4 mg/kg once per day, and those in the control group were treated with saline at the same dose. The animals in the⁶⁰Co irradiation group received ⁶⁰Co irradiation at the dose of 45 Gy and saline by intramuscular injection. Those in the ⁶⁰Co irradiation and zinc supplement group received ⁶⁰Co irradiation and zinc sulfate. The animals were killed at 1, 4 and 12 weeks after treatment. The fixation strengths were measured and compared among groups.

RESULTS AND CONCLUSION: (1) Zinc supplement made the titanium implants have higher fixation strengths, and reach a high level at 4 weeks after surgery. (2) ⁶⁰Co irradiation significantly inhibited the fixation strengths of the implants. After⁶⁰Co radiation, zinc supplement still could promote fixation strengths of titanium implants. (3) It is indicated that amount of zinc supplement after irradiation therapy can alleviate the negative effects of irradiation on implant fixation.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Cobalt, Zinc, Radiotherapy, Tissue Engineering

CLC Number:

R318

Chen Hai-jun, Lin Jun-zhou, Qian Qi-chun, Yu Shu-xiang, Nan Fu-qing, Yang Bo-cheng, Zhang Teng, Zhang Jing-bo, Zhang An-sheng. Effects of ⁶⁰Co irradiation and trace element zinc on fixation strengths of titanium implant[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(25): 3764-3770.

Figures/Tables 2

References

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Effects of ⁶⁰Co irradiation and trace element zinc on fixation strengths of titanium implant

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