Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (20): 3219-3225.doi: 10.3969/j.issn.2095-4344.3210

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Irisin mediates protective effects on failing heart via integrin alpha V receptors

Wang Jing, Wu Jiangbo   

  1. Tianjin University of Sport, Tianjin 301617, China
  • Received:2020-08-04 Revised:2020-08-07 Accepted:2020-09-26 Online:2021-07-18 Published:2021-01-15
  • Contact: Wu Jiangbo, MD candidate, Assistant researcher, Tianjin University of Sport, Tianjin 301617, China
  • About author:Wang Jing, Master, Experimentalist, Tianjin University of Sport, Tianjin 301617, China
  • Supported by:
    the Youth Project of Tianjin Natural Science Foundation, No. 18JCQNJC12400 (to WJB), the Third Level of “131” Innovative Talents Training Project in Tianjin (to WJB)

Abstract: BACKGROUND: Exercise stimulates skeletal muscle, myocardium and fat tissues to release irisin, and it exerts various effects on muscle and non-muscle tissues through autocrine, paracrine and endocrine pathways. Clinically, serum irisin level is used as an important indicator for diagnosing heart failure and evaluating its severity as well as a potential target for treating heart failure. 
OBJECTIVE: To explore the mechanism by which exercise-induced irisin exerts myocardial protection from the perspective of receptors.  
METHODS: SCI, PubMed, and CNKI were searched for relevant documents published from 1990 to 2020. The search terms included “irisin; integrin αV; aerobic exercise; chronic heart failure; myocardial mitochondria” in English and Chinese, respectively. According to the inclusion criteria and exclusion criteria, 68 authoritative and representative literatures were selected for review.
RESULTS AND CONCLUSION: Irisin plays an important role in maintaining normal cardiac function, and its cardioprotection is related to the improvement of mitochondrial function. Integrin αV is a novel specific receptor of irisin, which can transmit extracellular signals into cells through outside-in signals. Integrin αV mediates the effects of irisin on myocardial mitochondria, including oxidative stress, biosynthesis and mitophagy, which provides a new therapy for aerobic exercise or irisin to improve heart failure.

Key words: exercise, irisin, integrin, myocardial protection L, review

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