Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (17): 2781-2788.doi: 10.3969/j.issn.2095-4344.3170

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Treating lumbar disc herniation of blood stasis type with Chinese herbs, acupuncture, moxibustion, and massage: a Bayesian network Meta-analysis

Zhang Chongfeng1, Li Xianlin2, Peng Weibing2, Jia Hongsheng1, Cai Lei1    

  1. 1Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China; 2Department of Orthopedics, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
  • Received:2020-05-13 Revised:2020-05-16 Accepted:2020-06-12 Online:2021-06-18 Published:2021-01-08
  • Contact: Li Xianlin, Master’s supervisor, Department of Orthopedics, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
  • About author:Zhang Chongfeng, Master candidate, Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China

Abstract: OBJECTIVE: Traditional Chinese medicine (TCM), acupuncture, and massage have irreplaceable effects in the treatment of lumbar disc herniation. Currently, although pairwise comparisons are mostly conducted due to the diversity of treatment measures, there is still a lack of comparing the therapeutic efficacy among various measures. In this study, we conducted a Bayesian network Meta-analysis to evaluate the therapeutic efficacy of TCM therapies in patients with  lumbar disc herniation of blood stasis type as well as pain relief after treatment. 
METHODS: CNKI, VIP, WanFang, PubMed, and the Cochrane Library were searched for randomized controlled trials regarding TCM treatment of blood stasis type lumbar disc herniation. The retrieval date was from inception until February 2020. Two researchers independently selected literature, extracted data and evaluated quality and risk deviation according to the set criteria. Stata 14.2 was used to draw a network structure chart, prediction interval chart and comparison-correction funnel chart of publication bias. Ge MTC version 0.14.3 was used to carry out a network Meta-analysis. 
RESULTS: In total, 28 randomized controlled trials were included in this study, with a total of 2 508 patients with lumbar disc herniation. These trials involved 11 treatment measures, including TCM, acupuncture, moxibustion, massage, western medicine, acupuncture and moxibustion, TCM + moxibustion, massage + moxibustion, TCM + acupuncture, acupuncture + massage, acupuncture + massage + TCM. According to the results of Cochrane’s biased risk tool evaluation, 21 of the 28 articles included were evaluated as high risk, and 7 articles were evaluated as unclear. The results of network meta-analysis showed that: in terms of efficiency, other treatment measures are superior to western medicine, moxibustion, acupuncture, TCM + moxibustion, massage + moxibustion, TCM + acupuncture, acupuncture + massage, acupuncture + massage + TCM are superior to traditional Chinese medicine, moxibustion, acupuncture, massage + moxibustion, TCM + acupuncture are superior to acupuncture, and massage + moxibustion is superior to massage. In terms of Visual Analogue Scale score, other treatments are better than western medicine, TCM + moxibustion, massage + moxibustion, TCM + acupuncture, acupuncture + massage + TCM are better than TCM. Efficiency in descending order is as follows: massage + moxibustion > TCM + moxibustion > acupuncture > acupuncture + massage + TCM > TCM + acupuncture > moxibustion > acupuncture + massage > massage > acupuncture > TCM > western medicine. The score of Visual Analogue Scale from the best to the worst is as follows: massage + moxibustion > acupuncture + massage + TCM > TCM + moxibustion > TCM + acupuncture > acupuncture > acupuncture + massage > moxibustion > massage > acupuncture > TCM > western medicine. 
CONCLUSION: Existing evidence indicates massage + moxibustion is superior to the other 10 kinds of interventions; therefore, the combination therapy is mostly superior to the single therapy. Exact results should certainly be confirmed by a large amount of randomized controlled trials. 

Key words: bone, lumbar vertebrae, intervertebral disc, blood stasis syndrome, acupuncture, massage, traditional Chinese medicine, western medicine, pain, network Meta-analysis

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