Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (17): 2650-2656.doi: 10.3969/j.issn.2095-4344.3136
Previous Articles Next Articles
Zhang Lei, Yan Yu, Liu Yin, Xu Long, Yang Xinglei, Liu Yujia
Received:
2020-04-16
Revised:
2020-04-22
Accepted:
2020-05-27
Online:
2021-06-18
Published:
2021-01-08
Contact:
Liu Yujia, PhD, Lecturer, School of Physical Education, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, China
About author:
Zhang Lei, School of Physical Education, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, China
Supported by:
CLC Number:
Zhang Lei, Yan Yu, Liu Yin, Xu Long, Yang Xinglei, Liu Yujia. An 8-week aerobic exercise improves obesity-induced myocardial fibrosis: role of nuclear factor-erythroid 2 p45-related factor 2 pathway[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(17): 2650-2656.
[1] GONÇALVES N, SILVA AF, RODRIGUES PG, et al. Early cardiac changes induced by a hypercaloric Western-type diet in “subclinical” obesity. Am J Physiol Heart Circ Physiol. 2016;310(6):H655-666. [2] BLANKE K, SCHLEGEL F, RAASCH W, et al. Effect of Angiotensin(1-7) on Heart Function in an Experimental Rat Model of Obesity. Front Physiol. 2015;6:392. [3] MUKHERJEE D, SEN S. Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats. Circ Res. 1990; 67(6):1474-1480. [4] BERK BC, FUJIWARA K, LEHOUX S. ECM remodeling in hypertensive heart disease. J Clin Invest. 2007;117(3):568-575. [5] KOSMALA W, PLAKSEJ R, PRZEWLOCKA-KOSMALA M, et al. Matrix metalloproteinases 2 and 9 and their tissue inhibitors 1 and 2 in premenopausal obese women: relationship to cardiac function. Int J Obes (Lond). 2008;32(5):763-771. [6] WANG W, LI S, WANG H, et al. Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins. J Mol Cell Cardiol. 2014;72:305-315. [7] 朱磊,路瑛丽,冯连世,等.不同配方高脂饲料构建SD大鼠肥胖模型的实验研究[J].中国运动医学杂志,2016,35(7):642-647. [8] MARTINS F, CAMPOS DH, PAGAN LU, et al. High-fat Diet Promotes Cardiac Remodeling in an Experimental Model of Obesity. Arq Bras Cardiol. 2015;105(5): 479-486. [9] WANG Z, LI L, ZHAO H, et al. Chronic high fat diet induces cardiac hypertrophy and fibrosis in mice. Metabolism. 2015;64(8):917-925. [10] CARROLL JF, TYAGI SC. Extracellular matrix remodeling in the heart of the homocysteinemic obese rabbit. Am J Hypertens. 2005;18(5 Pt 1):692-698. [11] PASSINO C, BARISON A, VERGARO G, et al. Markers of fibrosis, inflammation, and remodeling pathways in heart failure. Clin Chim Acta. 2015;443:29-38. [12] BURCHFIELD JS, XIE M, HILL JA. Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation. 2013;128(4):388-400. [13] MARTOS R, BAUGH J, LEDWIDGE M, et al. Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. Circulation. 2007;115(7):888-895. [14] JUGDUTT BI. Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways. Curr Drug Targets Cardiovasc Haematol Disord. 2003;3(1):1-30. [15] KWAK HB. Aging, exercise, and extracellular matrix in the heart. J Exerc Rehabil. 2013;9(3):338-347. [16] LORENZO O, RAMÍREZ E, PICATOSTE B, et al. Alteration of energy substrates and ROS production in diabetic cardiomyopathy. Mediators Inflamm. 2013;2013: 461967. [17] 尹懿,张琳,徐安杰,等.有氧运动对老年自发性高血压大鼠心肌纤维化的影响[J].北京体育大学学报,2015,38(12):68-72. [18] 李丹,王世强,何艳群,等.运动抑制转化生长因子β1/smad信号通路对糖尿病大鼠心肌纤维化影响的研究[J].中国糖尿病杂志,2018,26(9):780-786. [19] 王世强. TGF-β1/Smad信号通路在运动性心肌纤维化发生中的作用研究[D].上海:上海体育学院,2016. [20] 王世强,常芸,李丹,等.运动性心肌纤维化的发生特征、可能机制和消退逆转[J].体育科学,2018,38(11):81-91. [21] XIE J, ZHANG Q, ZHU T, et al. Substrate stiffness-regulated matrix metalloproteinase output in myocardial cells and cardiac fibroblasts: implications for myocardial fibrosis. Acta Biomater. 2014;10(6):2463-2472. [22] MATSUSAKA H, IDE T, MATSUSHIMA S, et al. Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload. Hypertension. 2006;47(4):711-717. [23] HAFSTAD AD, LUND J, HADLER-OLSEN E, et al. High- and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity. Diabetes. 2013;62(7):2287-2294. [24] MA N, LIU HM, XIA T, et al. Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide. Can J Physiol Pharmacol. 2018;96(9):902-908. [25] XIAO L, HE H, MA L, et al. Effects of miR-29a and miR-101a Expression on Myocardial Interstitial Collagen Generation After Aerobic Exercise in Myocardial-infarcted Rats. Arch Med Res. 2017;48(1):27-34. [26] LIAO PH, HSIEH DJ, KUO CH, et al. Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts. Oncotarget. 2015;6(34):35383-35394. [27] ZHANG H, MENG J, YU H. Trimethylamine N-oxide Supplementation Abolishes the Cardioprotective Effects of Voluntary Exercise in Mice Fed a Western Diet. Front Physiol. 2017;8:944. [28] BOSTICK B, AROOR AR, HABIBI J, et al. Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels. Metabolism. 2017;66:14-22. [29] 汤明月.有氧运动及饮食干预对肥胖大鼠心肌胶原网络及LOX表达的影响[D].上海:上海体育学院,2014. [30] XU X, WAN W, POWERS AS, et al. Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats. J Mol Cell Cardiol. 2008;44(1):114-122. [31] KANDASAMY AD, CHOW AK, ALI MA, et al. Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix. Cardiovasc Res. 2010; 85(3):413-423. [32] DANG L, WANG Y, XUE Y, et al. Low-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS. Oncol Rep. 2015; 34(3):1478-1486. [33] FRANCIS STUART SD, DE JESUS NM, LINDSEY ML, et al. The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction. J Mol Cell Cardiol. 2016;91:114-122. [34] MEWHORT HE, LIPON BD, SVYSTONYUK DA, et al. Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1. Am J Physiol Heart Circ Physiol. 2016;310(6):H716-724. [35] LATELLA G. Redox Imbalance in Intestinal Fibrosis: Beware of the TGFβ-1, ROS, and Nrf2 Connection. Dig Dis Sci. 2018;63(2):312-320. [36] HORN RC, GELATTI GT, MORI NC, et al. Obesity, bariatric surgery and oxidative stress. Rev Assoc Med Bras (1992). 2017;63(3):229-235. [37] ROWICKA G, DYLĄG H, AMBROSZKIEWICZ J, et al. Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity. Oxid Med Cell Longev. 2017;2017: 5621989. [38] GLENN DJ, CARDEMA MC, NI W, et al. Cardiac steatosis potentiates angiotensin II effects in the heart. Am J Physiol Heart Circ Physiol. 2015;308(4):H339-350. [39] ABDURRACHIM D, CIAPAITE J, WESSELS B, et al. Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta. 2014;1842(10):1525-1537. [40] RICHTER K, KIETZMANN T. Reactive oxygen species and fibrosis: further evidence of a significant liaison. Cell Tissue Res. 2016;365(3):591-605. [41] SAW CL, YANG AY, HUANG MT, et al. Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages. Cell Biosci. 2014;4:39. [42] GUAN Y, TAN Y, LIU W, et al. NF-E2-Related Factor 2 Suppresses Intestinal Fibrosis by Inhibiting Reactive Oxygen Species-Dependent TGF-β1/SMADs Pathway. Dig Dis Sci. 2018;63(2):366-380. [43] HOU N, ZHAO G, CAI S, et al. Nrf2 is a Key Regulator on Puerarin Preventing Cardiac Hypertrophy and Upregulating Metabolic Enzymes Ugt1a1 and Ugt1a9 in Rats. Circulation Research.2018;123(Suppl_1): A576. [44] CHEN RR, FAN XH, CHEN G, et al. Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis. Chem Biol Interact. 2019;302:11-21. [45] ERKENS R, KRAMER CM, LÜCKSTÄDT W, et al. Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function. Free Radic Biol Med. 2015;89:906-917. [46] NARASIMHAN M, RAJASEKARAN NS. Exercise, Nrf2 and Antioxidant Signaling in Cardiac Aging. Front Physiol. 2016;7:241. [47] GOUNDER SS, KANNAN S, DEVADOSS D, et al. Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One. 2012;7(9):e45697. [48] SUN M, HUANG C, WANG C, et al. Ginsenoside Rg3 improves cardiac mitochondrial population quality: mimetic exercise training. Biochem Biophys Res Commun. 2013;441(1):169-174. [49] BOS I, DE BOEVER P, INT PANIS L, et al. Negative effects of ultrafine particle exposure during forced exercise on the expression of Brain-Derived Neurotrophic Factor in the hippocampus of rats. Neuroscience. 2012;223:131-139. [50] KUMAR RR, NARASIMHAN M, SHANMUGAM G, et al. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. J Transl Med. 2016;14:86. [51] JIANG HK, MIAO Y, WANG YH, et al. Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis. Clin Exp Pharmacol Physiol. 2014;41(3):192-201. |
[1] | Zhang Yu, Tian Shaoqi, Zeng Guobo, Hu Chuan. Risk factors for myocardial infarction following primary total joint arthroplasty [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(9): 1340-1345. |
[2] | Xiao Guoqing, Liu Xuanze, Yan Yuhao, Zhong Xihong. Influencing factors of knee flexion limitation after total knee arthroplasty with posterior stabilized prostheses [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(9): 1362-1367. |
[3] | Zhang Chong, Liu Zhiang, Yao Shuaihui, Gao Junsheng, Jiang Yan, Zhang Lu. Safety and effectiveness of topical application of tranexamic acid to reduce drainage of elderly femoral neck fractures after total hip arthroplasty [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(9): 1381-1386. |
[4] | Wang Haiying, Lü Bing, Li Hui, Wang Shunyi. Posterior lumbar interbody fusion for degenerative lumbar spondylolisthesis: prediction of functional prognosis of patients based on spinopelvic parameters [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(9): 1393-1397. |
[5] | Zhang Chao, Lü Xin. Heterotopic ossification after acetabular fracture fixation: risk factors, prevention and treatment progress [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(9): 1434-1439. |
[6] | Chen Jinping, Li Kui, Chen Qian, Guo Haoran, Zhang Yingbo, Wei Peng. Meta-analysis of the efficacy and safety of tranexamic acid in open spinal surgery [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(9): 1458-1464. |
[7] | Shu Wenbo, Chen Mengchi, Li Hua, Huang Liqian, Huang Binbin, Zhang Wenhai, Wu Yachen, Wang Zefeng, Li Qiaoli, Liu Peng. Correlation between body fat distribution and characteristics of daily physical activity in college students [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1277-1283. |
[8] | Gu Xia, Zhao Min, Wang Pingyi, Li Yimei, Li Wenhua. Relationship between hypoxia inducible factor 1 alpha and hypoxia signaling pathway [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1284-1289. |
[9] | Ji Zhixiang, Lan Changgong. Polymorphism of urate transporter in gout and its correlation with gout treatment [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1290-1298. |
[10] | Wu Xun, Meng Juanhong, Zhang Jianyun, Wang Liang. Concentrated growth factors in the repair of a full-thickness condylar cartilage defect in a rabbit [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1166-1171. |
[11] | Shen Jinbo, Zhang Lin. Micro-injury of the Achilles tendon caused by acute exhaustive exercise in rats: ultrastructural changes and mechanism [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1190-1195. |
[12] | Li Jing, Xie Jianshan, Cui Huilin, Cao Ximei, Yang Yanping, Li Hairong. Expression and localization of diacylglycerol kinase zeta and protein kinase C beta II in mouse back skin with different coat colors [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1196-1200. |
[13] | Zeng Zhen, Hu Jingwei, Li Xuan, Tang Linmei, Huang Zhiqiang, Li Mingxing. Quantitative analysis of renal blood flow perfusion using contrast-enhanced ultrasound in rats with hemorrhagic shock during resuscitation [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1201-1206. |
[14] | Tang Hui, Yao Zhihao, Luo Daowen, Peng Shuanglin, Yang Shuanglin, Wang Lang, Xiao Jingang. High fat and high sugar diet combined with streptozotocin to establish a rat model of type 2 diabetic osteoporosis [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1207-1211. |
[15] | Chai Le, Lü Jianlan, Hu Jintao, Hu Huahui, Xu Qingjun, Yu Jinwei, Quan Renfu. Signal pathway variation after induction of inflammatory response in rats with acute spinal cord injury [J]. Chinese Journal of Tissue Engineering Research, 2021, 25(8): 1218-1223. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||