Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (30): 4539-4546.doi: 10.3969/j.issn.2095-4344.2016.30.019

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Functional bone tissue engineering scaffold used to repair tuberculosis bone defect

Sun Xiao-hu1, Yuan Jing1, Zhang Yu2, Qiao Yong-jie3, Cao Xue-fei3, Meng Lei3, Gao Zhan-wang3, Zhen Ping3   

  1. 1Second Department of Orthopedics, People’s Hospital of Qingyang City, Qingyang, 745000, Gansu Province, China; 2Department of Orthopedics, Second People’s Hospital of Gansu Province, Lanzhou 730000, Gansu Province, China; 3PLA Orthopedics Center, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730050, Gansu Province, China
  • Online:2016-07-15 Published:2016-07-15
  • Contact: Zhen Ping, M.D., Professor, Master’s supervisor, Chief physician, PLA Orthopedics Center, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730050, Gansu Province, China
  • About author:Sun Xiao-hu, Associate chief physician, Second Department of Orthopedics, People’s Hospital of Qingyang City, Qingyang, 745000, Gansu Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81371983

Abstract:

BACKGROUND: Repairing tuberculosis bone defect has become a research focus with the development of anti-tuberculosis functional bone tissue engineering scaffold.
OBJECTIVE: To evaluate the preparation, drug release performance and osteogenic properties of the anti-tuberculosis functional bone tissue engineering scaffold.
METHODS: PubMed, Chinese Journal Full-text Database, Wanfang databases were searched by computer for articles addressing functional bone tissue engineering scaffold for repair of tuberculosis bone defect. The keywords were “bone tissue engineering scaffold; tuberculosis; bone defect” in English and Chinese. RESULTS AND CONCLUSION: The anti-tuberculosis functional bone tissue engineering scaffold has good drug delivery, biocompatibility, osteogenic properties and anti-tuberculosis properties. As a good choice to avert bone defect relapse, the scaffold enables a long and stable drug release into bone defects to enhance the therapeutic efficacy of anti-tuberculosis drugs topically. Given the technical deficiencies, we can only combine two drugs with the anti-tuberculosis bone tissue engineering scaffold, although the combined use of three or four anti-tuberculosis drugs is preferred. Additionally, a complete course of anti-tuberculosis treatment often lasts for 6-12 months, which cannot be achieved by the existing anti-tuberculosis bone tissue engineering scaffold. Up to now, the effect of this scaffold has not yet been confirmed in animal models, although how to prepare this scaffold has been reported.

Key words: Tuberculosis, Osteoarticular, Braces, Tissue Engineering

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