Unstable pelvic fractures treated with cancellous bone screw fixation: inflammatory factor levels

doi:10.3969/j.issn.2095-4344.2016.22.011

Abstract

Abstract:

BACKGROUND: After different metal fixation materials are implanted into the human body, peripheral tissue inflammatory response to varying degrees will appear in the early stage. Poor biocompatibility of the corresponding materials will lead to prolonged duration of inflammatory reaction.

OBJECTIVE: To investigate the inflammatory factor level changes and biocompatibility of cancellous bone screw fixation in treatment of unstable pelvic fractures.

METHODS: A total of 61 patients with unstable pelvic fractures were randomly divided into the observation group (29 cases) and the control group (32 cases). The 29 patients in the observation group underwent cancellous bone screw fixation. The 32 patients in the control group underwent conventional therapy. During 12 months of follow-up, Majeed function score and inflammatory factor level changes and adverse events were observed and compared between the two groups.

RESULTS AND CONCLUSION: (1) Majeed function scores were significantly higher in both groups after treatment as compared with that preoperatively (all P < 0.05). The Majeed function scores were significantly higher in the observation group than in the control group 12 months after treatment (P < 0.05). (2) Inflammatory factor levels: Interleukin 6, C- reactive protein, and tumor necrosis factor alpha levels were significantly lower in both groups after treatment as compared with that preoperatively (all P < 0.05). No significant difference in above indexes was found between the two groups before and after treatment (P > 0.05). (3) Adverse events: one case affected incision infection after operation in the observation group. In the control group, four patients experienced incision infection. One suffered from nonunion, and one had bone necrosis. Above patients were treated in time, and were cured, so there were no deaths. There were significant differences in the incidence of adverse events between the 2 groups (P < 0.05). (4) The research results show that cancellous bone screw fixation for unstable pelvic fractures can obtain satisfactory clinical results, and have good biocompatibility.
中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Pelvis, Fractures, Bone, Internal Fixators, Tissue Engineering

CLC Number:

R318

Xu Meng-fan, Zhuang Huan-xiong, Mai Hu-qiang, Chen Shi-xiong. Unstable pelvic fractures treated with cancellous bone screw fixation: inflammatory factor levels[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(22): 3272-3278.

Figures/Tables 2

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