Bone marrow mesenchymal stem cells combined with endothelial progenitor cells for repair of alveolar bone defect in ovariectomized rats

doi:10.3969/j.issn.2095-4344.2016.19.002

Abstract

Abstract:

BACKGROUND: Numerous studies have demonstrated that estrogen can regulate the proliferation and migration of endothelial progenitor cells (EPCs), while EPCs can also promote the function and activity of bone marrow mesenchymal stem cells (BMSCs) in vitro.
OBJECTIVE: To evaluate the ability of the BMSCs and EPCs which construct the composite cell sheet in the repair of alveolar bone defect in ovariectomized rats.
METHODS: BMSCs/EPCs composite sheet, EPCs sheet and BMSCs sheet were respectively implanted into the defects of the alveolar bone in ovariectomized rats. Rats with no implantation served as control group. Repaired alveolar bone was assessed by gross examination, histological observation and micro-CT scan at 2, 4, 8 weeks after operation.
RESULTS AND CONCLUSION: BMSCs/EPCs composite sheet has greater osteogensis activity and bone repair capacity than BMSCs or EPCs sheet alone.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Osteoporosis, Postmenopausal, Alveolar Bone Loss, Bone Marrow, Mesenchymal Stem Cells, Tissue Engineering

CLC Number:

R394.2

Wen Yi, Yang Hong-xu, Liu Qian, Liang Yuan, Liu Zhu-ying, Ding Yin. Bone marrow mesenchymal stem cells combined with endothelial progenitor cells for repair of alveolar bone defect in ovariectomized rats[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(19): 2748-2755.

Figures/Tables 1

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