Effect of body mass index on outcomes of in vitro fertilization for infertile females at different ages

doi:10.3969/j.issn.2095-4344.2016.15.012

Abstract

Abstract:

BACKGROUND: The effect of body mass index (BMI) on the outcomes of in vitro fertilization (IVF) is controversial. Some scholars suggested that the higher BMI, the lower rate of pregnancy, and the higher rate of abortion. However, some others got the different results. To data, the effects of BMI on the pregnancy outcomes in females at different ages are rarely reported.

OBJECTIVE: To explore the effect of BMI on the pregnancy outcomes of IVF for infertile women atdifferent ages.

METHODS: A total of 902 cycles undergoing IVF were divided into two groups according to the age: ≤ or ＞ 35 years old groups. The patients in each group were then divided into four subgroups according to BMI: low weight, normal weight, excess weight, and obesity subgroups, respectively.

RESULTS AND CONCLUSION: With increasing BMI, the average dosage of gonadotropins was increased gradually in two both of age groups (P < 0.05). In the ≤ 35 years old, the levels of estrogens on the day of injecting human chorionic gonadotropin was significantly lower in obesity group than the other subgroups (P < 0.05); the rates of empty follicle in excess weight and obesity subgroups were significantly higher than that in normal weight subgroup (P < 0.008 23). The fertilization rate and clinical pregnancy rate of in obesity subgroup were significantly lower than those in the other subgroups (P < 0.05). In the > 35 years old group, the empty follicle rate in obesity subgroup was significantly higher than that in normal weight subgroup (P < 0.008 23). Fertilization rate in excess weight and obesity subgroups was significantly lower than that in the normal weight subgroup (P < 0.008 23). There were no significant differences in cleavage rate, cycle cancellation rate, implantation rate, biochemical pregnancy rate and abortion rate between four subgroups (P > 0.05). These findings suggest that in the females at the younger age, BMI not only affects the quality of follicles and fertilization rate; but with increasing BMI, clinical pregnancy rate is decreased obviously. However in the females at the older age, BMI only affects the follicular quality, embryo quality and fertilization rates; there are no significant differences in the outcomes of pregnancy in the four subgroups. BMI have effects on pregnancy outcomes of IVF, and the effects are much greater in the younger female group.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Body Mass Index, Fertilization in Vitro, Obesity, Pregnancy Outcome

Li Pei, Zhang Jing, Jin Xuan. Effect of body mass index on outcomes of in vitro fertilization for infertile females at different ages[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(15): 2212-2217.

Figures/Tables 4

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