Application of concentrated growth factor in maxillary sinus lift: variation in peri-implant bone levels

doi:10.3969/j.issn.2095-4344.2015.47.006

Abstract

Abstract:

BACKGROUND: Many experiments and clinical studies have reported that venous blood, absorbable collagen sponge and rich fibrin clot, without the use of bone graft material, can all promote new bone formation; therefore, whether only transplanting concentrated growth factor in the maxillary sinus lift could effectively promote bone regeneration?

OBJECTIVE: To conduct the maxillary sinus lift with concentrated growth factor as the graft material, and to observe the peri-implant bone level change.

METHODS: Totally 26 patients were involved, including 14 males and 12 females, aged 35-73 years. Maxillary sinus lift was conducted and autologous concentrated growth factor was taken as the graft material. Astra Tech implants were implanted simultaneously. Patients were divided into 6-12 months, 13-18 months and > 18 months groups according to the follow-up time. Patients were divided into ≤ 5 mm, 5-7 mm, and ≥ 7 mm groups according to the preoperative alveolar bone height. Patients were divided into ≤ 2 mm, 2.0-3.0 mm, and ≥3 mm groups according to the postoperative maxillary sinus lift height. The survival rate of implants and marginal bone level changes were observed during the follow-up.

RESULTS AND CONCLUSION: Totally 44 implants were implanted, of which 43 implants were considered as successful repair during the 6-18 months of postoperative follow-up. The survival rate of implants was 98%. There were no significant differences in the changes of mesial, distal and middle marginal bone levels between different follow-up time groups. The maxillary sinus lift with transplantation of concentrated growth factor resulted in a good osseointegration within 6-18 months post-operation. In addition, no significant differences were found in the changes of mesial, distal and middle marginal bone levels between different residual alveolar bone height groups, as well as between different maxillary sinus lift height groups. It showed that the residual alveolar bone height and maxillary sinus lifting height had no significant effect on the peri-implant bone formation. Briefly, these findings demonstrate that the maxillary sinus lift with concentrated growth factor transplantation can result in a high survival rate of implants that are simultaneous implanted, and the alveolar bone around the implant is stable. But the long-term effect needs further observation.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Biocompatible Materials, Maxillary Sinus, Dental Implantation, Dental Implants, Alveolar Process, Tissue Engineering

Huang Na, Wu Feng, Li Ping, Liu Zi-ping, Lin Ju, Tang You-chao, Wang Yuan-qin. Application of concentrated growth factor in maxillary sinus lift: variation in peri-implant bone levels[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(47): 7575-7582.

Figures/Tables 8

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