Nano-hydroxyapatite/polyamide 66 composite for repair of early femoral head necrosis

doi:10.3969/j.issn.2095-4344.2015.34.011

Abstract

Abstract:

BACKGROUND: Nano-hydroxyapatite/polyamide 66 composite has good material-cell interface and three-dimensional porous network structure, and it can also be gradually degraded over time after implantation in the human body.

OBJECTIVE: To explore the effect of nano-hydroxyapatite/polyamide 66 in early repair of femoral head necrosis.

METHODS: A retrospective analysis was performed on clinical data of 62 cases of early osteonecrosis of the femoral head, including 32 males and 30 females, aged 34-51 years. These patients were divided into control group (31 cases) and observation group (31 cases) according to treatment methods. Core decompression with nano-hydroxyapatite/polyamide 66 implantation and core decompression with bone graft were respectively performed in the observation and control groups. Incidence of pain in the two groups was compared at 1 day after treatmen; and during the 12-month follow-up, the Harris score of the hip function in the two groups was compared.

RESULTS AND CONCLUSION: There was no significant difference in the visual analog scale scores between two groups at 1 day after treatment. The Harris scores in the observation group were significantly higher than those in the control group at 3 and 12 months after treatment (P < 0.05). There was no adverse reaction in the two groups. These findings indicate that nano-hydroxyapatite/polyamide 66 material for repair of early femoral head necrosis has good biocompatibility, and can obtain good effects on limb function recovery.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Hydroxyapatites, Nylons, Femur Head Necrosis

CLC Number:

R318

Yang Ming-min, Li Dai, Sun Yang. Nano-hydroxyapatite/polyamide 66 composite for repair of early femoral head necrosis [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(34): 5463-5467.

Figures/Tables 3

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