Association between the PvuII and XbaI polymorphisms in estrogen receptor alpha gene and risk of osteoarthritis: a Meta-analysis

doi:10.3969/j.issn.2095-4344.2015.33.029

Abstract

Abstract:

BACKGROUND: There are a lot of reports about the association between estrogen receptor α polymorphism and osteoarthritis susceptibility, but the results are still some controversial.

OBJECTIVE: To investigate the relationship between the estrogen receptor α gene PvuII, XbaI site polymorphisms and genetic susceptibility of osteoarthritis．

METHODS: A computer-based search of PubMed, web of science, Wanfang, CNKI, Weipu and China Biology Medicine Disc was performed for the published case-control studies addressing the association between estrogen receptor α gene PvuII, XbaI site polymorphism and osteoarthritis susceptibility. Odds radio (OR) and 95% confidence interval were used to analyze the correlation between estrogen receptor α gene PvuII, XbaI site polymorphism and osteoarthritis. Fixed or random effect models were selected for pooled OR calculation. Publication bias was assessed. All statistical analysis was constructed with Revman5.1 software．

RESULTS AND CONCLUSION: Nine case-control studies including 3 228 cases of osteoarthritis and 6 327 healthy controls were included. Overall, the pooled OR values of PvuII loci alleles and genotypes (C vs. T; CT vs. TT; CC vs. TT; CT+CC vs. TT; CC vs. CT+TT) were less than 1; the pooled OR values of Asian which grouped by region were greater than 1 (except CT vs. TT); the pooled OR values of Europe and the Americas were less than
1. The pooled OR values of XbaI loci alleles and genotypes (G vs. A; GA vs. AA; GG vs. AA; GA+GG vs. AA; GG vs. GA+AA) were less than 1; the pooled OR values of Asian which grouped by region were less than 1; the pooled OR value of Europe and the Americas were less than 1 (except GG vs. GA+AA). Estrogen receptor α gene PvuII, XbaI site polymorphism is not associated with osteoarthritis susceptibility. However, the susceptibility of PvuII loci in the Asian is a little higher compared with that of the Europeans and American population. On the contrary, the susceptibility of XbaI loci in the recessive genetic model of Europeans and American population is a little higher compared with that of the Asian, suggesting a possible role of ethnic differences in genetic backgrounds.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoarthritis, Estrogens, Polymorphism, Genetic

CLC Number:

R318

Xu Bo-yong, Fu Ying-xu, Asihaerjiang Maimaitiyiming, Cao Li, Guo Wen-tao. Association between the PvuII and XbaI polymorphisms in estrogen receptor alpha gene and risk of osteoarthritis: a Meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(33): 5408-5412.

Figures/Tables 4

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