Factors critical for creeping substitution of intracorporeal grafting following thoracolumbar fractures

doi:10.3969/j.issn.2095-4344.2013.53.003

Abstract

Abstract:

BACKGROUND: The occurrence of “eggshell” change after the pedicular screw reduction

is the main cause of reduction lose and kyphosis. Theoretically intracorporeal grafting in the juried vertebra could enhance the anterior supporting, but the clinical effects vary obviously and the specific cause is unclear.

OBJECTIVE: To understand the effect of defect size and the amount of bone grafting on the osteogenesis and to explore the histological factors concerning osteogenesis of intracorporeal grafting following thoracolumbar fractures.

METHODS: The two-different sizes bone defect models (1 cm³and 2 cm³ defect groups) in the lumbar vertebras of 12 sheep were made, and each group included six sheep. Different amount of autologous iliac bone was randomly grafted into the L_{1, 3, 5}vertebral segments according to grafting/bone defect ratios of 0.5, 0.75, 1.0, respectively. The grafting area of operated vertebra was separated for the imaging and histological analysis to understand the osteogenesis process.

RESULTS AND CONCLUSION: The bone histomorphometry and histological results of different grafting ratio in different size defects demonstrated excellent creeping substitution and osteogenesis in the grafting/cavity ratio larger than 0.75, and the grafting bone was substituted by fibrous tissue if the ratio was less than 0.75. Trabecular number, percent of trabecular area and mean trabecular plate height increased and trabecular separation decreased with the increment of grafting/cavity ratio. There was no significant difference between the grafting ratio 0.75 and 1.0, but they had obvious difference from ratio 0.5 subgroup. The sufficient grafting amount is critical for intracorpereal grafting, and the ratio of grafting/bone defect larger than 0.75 could produce satisfactory osteogenesis.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: fracture fixation, synostosis, thorax, spine

CLC Number:

R318

Shen Jun, Zou Tian-ming, Miao Ye, Wang Ye-feng, Xu Zheng-quan, Wang Dong-lai . Factors critical for creeping substitution of intracorporeal grafting following thoracolumbar fractures[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(53): 9113-9118.

Figures/Tables 2

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