Shape variation of optic nerve head by mechanical analysis using three-dimensional finite element model

doi:10.3969/j.issn.2095-4344.2013.50.015

Abstract

Abstract:

BACKGROUND: The measure and prediction of the shape of optic nerve head are the key issues for early diagnosis and duration prediction of glaucoma. Therefore, it is significant to research the shape variation of optic nerve head under high intraocular pressure.
OBJECTIVE: To establish three-dimensional finite element model of optic nerve head and to analyze the deformation of optic nerve head and the change in retina thickness after acute high intraocular pressure.
METHODS: Animal model of acute ocular hypertension was established by methods of anterior chamber perfusion. The tomographic images of the optic nerve head of a cat were obtained at the normal intraocular pressure and 5 320 Pa, 7 980 Pa, 10 640 Pa, 13 300 Pa, 15 960 Pa intraocular pressures using optical coherence tomography. Then, we measured the variation of retinal thickness at typical location. Basing on the tomographic images of optic nerve head of a cat at normal intraocular pressure, we obtained three-dimensional structure of retina and choroid using software MIMICS. Then three-dimensional model of optic nerve head was established by assembling the retina and choroid. The deformation of optic nerve head and the change in retinal thickness under high intraocular pressure were observed using software ABAQUS. The effectiveness of the model was verified by the experimental result.
RESULTS AND CONCLUSION: With the increase of intraocular pressure, the retinal thickness is thinner, the optic nerve head depth, width and the ratio of the depth to width are gradually increased. It suggests that the acute high intraocular pressure causes retinal thinning, optic nerve head widening and deepening. It is feasible to establish optic nerve head modeling in vivo by using optical coherence tomography, mechanical analysis can be applied to predict the shape variation of optic nerve head, which is significant to further deduce the pathological process of glaucoma.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: high intraocular pressure, glaucoma, imaging, three-dimensional, finite element analysis, retina

CLC Number:

R318

Qi Xin-zheng, Wei Chao, Yang Jia-yan, Mu Jing, Zhang Kun-ya, Liu Zhi-cheng, Qian Xiu-qing. Shape variation of optic nerve head by mechanical analysis using three-dimensional finite element model[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2013.50.015.

Figures/Tables 1

References

[1] Quigley HA, Addicks EM, Green WR, et al. Optic nerve damage in human glaucoma. II: The site of injury and susceptibility to damage. Arch Ophthalmol.1981;99(4): 635-649.

[2] 季宝玲, 游逸安, 方爱武, 等. OCT测量视网膜神经纤维层和黄斑厚度在青光眼早期诊断中的意义[J]. 眼视光学杂志,2008, 10(1): 54-58.

[3] 胡赛静, 邱翎. 正常眼与原发性开角型青光眼的OCT视盘参数分析的对比研究[J]. 临床眼科杂志, 2007, 15(1):26-28.

[4] 戴惟葭, 边俊杰, 杨惠青, 等. 急性闭角型青光眼视网膜神经纤维层改变的一年动态观察[J]. 眼科, 2010, 19(5): 331-335.

[5] Sigal IA, Flanagan JG, Tertinegg I, et al. Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties. Biomech Model Mechanobiol. 2009;8:99-109.

[6] Yang H, Downs JC, Sigal IA, et al. Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions. Invest Ophthalmol Vis Sci. 2009;50:5785-5799.

[7] 杨翎, 袁志兰, 占慧琴. FD-OCT测量视盘周围视网膜神经纤维层和视神经乳头参数在青光眼早期诊断中的意义[J]. 南京医科大学学报:自然科学版, 2010,30(7): 1026-1030.

[8] 杨新光, 刘钊, 于敬妮, 等. 原发性青光眼早期视盘参数与视野缺损的关系[J]. 临床眼科杂志, 2009, 17(4):295-299.

[9] 徐亮, 夏翠然, 杨桦, 等. 正常人不同类型视乳头及早期青光眼患者视乳头形态学研究[J]. 中华眼科杂志, 2002, 38(6): 325-328.

[10] Quigley HA, Addicks EM. Quantitative studies of retinal nerve fiber layer defects. Arch Ophthalmol. 1982;100: 807-814.

[11] Quigley HA, Addicks EM. Regional differences in the stucture of the laminal cribeosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol. 1981;99: 137-143.

[12] He DQ, Ren ZQ. A biomathematical model for pressure- dependent lamina cribrosa behavior. J Biomech. 1999; 32: 579-584.

[13] Belleza AJ, Hart RT, Burgoyne CF. The optic nerve head as a biomechanical structure: initial finite element modeling. Invest OphthalmolVis Sci. 2000;41(10): 2991-3000.

[14] Yang H, Downs JC, Bellezza A, et al. 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: prelaminar neural tissues and cupping. Invest Ophthalmol Vis Sci. 2007;48:5068-5084.

[15] Sigal IA, Flinagan JG, Ethier CR. Finite element modeling of optic nerve head. Invest Ophthalmol Vis Sci. 2004;45(12): 4378- 4387.

[16] Sigal IA, Flinagan JG, Tertinegg I, et al. Reconstruction of human nerve heads for finite element modeling. Tech Health Care. 2005;13: 313 -329.

[17] Sigal IA, Flanagan JG, Tertinegg I, et al. 3D morphometry of the human optic nerve head. Exp Eye Res. 2010;90:70-80.

[18] Roberts MD, Grau V, Grimm J, et al. Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2009; 50(2): 681-690.

[19] Roberts MD, Liang Y, Sigal IA, et al. Correlation between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes. Invest Ophthalmol Vis Sci. 2010;51(1):295-307.

[20] Sigal IA. An applet to estimate the IOP-induced stress and strain within the optic nerve head. Invest Ophthalmol Vis Sci. 2011;52(8): 5497-5506.

[21] Sigal IA, Yang H, Roberts MD, et al. IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models. Invest Ophthalmol Vis Sci. 2011; 52(3):1896-1907.

[22] Norman RE, Flanagan JG, Sigal IA, et al. Finite element modeling of the human sclera: Influence on optic nerve head biomechanics and connections with glaucoma. Exp Eye Res. 2011;93: 4-12.

[23] Chen TC, Cense B, Miller JW, et al. Histologic correlation of in vivo optical coherence tomography images of the human retina. Am J Ophthalmol. 2006;141:1165-1168.

[24] Toth CA, Birngruber R, Boppart SA, et al. Argon laser retinal lesions evaluated in vivo by optical coherence tomography. Am J Ophthalmol. 1997;123:188-198.

[25] Toth CA, Narayan DG, Boppart SA, et al. A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy. Arch Ophthalmol. 1997;115: 1425-1428.

[26] Strouthidis NG, Fortune B, Yang H, et al. longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma. Invest Ophthalmol Vis Sci. 2011;52(3): 1206-1219.

[27] Yang H, Qi J, Hardin C, et al. Spectral-domain optical coherence tomography enhanced depth imaging of the normal and glaucomatous nonhuman primate optic nerve head. Invest Ophthalmol Vis Sci. 2012;53: 394-405.

[28] Reis AS, Sharpe GP, Yang H, et al. Optic disc margin anatomy in patients with glaucoma and normal controls with spectral domain optical coherence tomography. Ophthalmology. 2012;119:738-747.

[29] Inoue R, Hangai M, Kotera Y, et al. Three-dimensional high-speed optical coherence tomography imaging of lamina cribrosa in glaucoma. Ophthalmology. 2009;116: 214-222.

[30] Ruggeri M, Wehbe H, Jiao S, et al. In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2007;48:1808-1814.

[31] Abbott CJ, McBrien NA, Grunert U, et al. Relationship of the optical coherence tomography signal to underlying retinal histology in the tree shrew (Tupaia belangeri). Invest Ophthalmol Vis Sci. 2009;50:414-423

[32] Qiu JF, Qian XQ, Cui QQ, et al. Three-Dimensional Reconstruction and Finite Element Modeling Analysis of the Rabbit Optic Nerve Head in Acute High Intraocular Pressure. Jap J Appl Phys. 2012;51(6): 067001.

[33] Chen K, Rowley AP, Weiland JD. Elastic properties of porcine ocular posterior soft tissues. J Biomed Mater Res A. 2010; 93(2):634-645.

[34] Del Priore LV. Stiffness of retinal and choroidal tissue: a surface wrinkling analysis of epiretinal membranes and choroidal folds. Am J Ophthalmol. 2006;142(3):435-440.

[35] 钱勇, 刘菊, 段文静, 等. 频域OCT检测青光眼视乳头及黄斑区容积改变的初步研究[J]. 临床眼科杂志, 2011,19(3): 200-203.

[36] Maruko I, Iida T, Sugano Y, et al. Subfoveal retinal and choroidal thickness after verteporfin photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2011; 151(4):594-603.

[37] Park HY, Jeon SH, Park CK. Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma. Ophthalmology. 2012;119: 10-20.

[38] Park SC, De Moraes CG, Teng CC, et al. Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma. Ophthalmology. 2012;119: 3-9.

[39] 张昆亚, 殷莹, 张伟, 等. 利用连通器原理设计体内加压及眼球体积监测装置观测兔眼球蠕变特性[J]. 中国组织工程研究与临床康复, 2009, 43(13): 8499- 8502.

[40] 王兰, 梁远波, 王宁利, 等.原发性开角型和闭角型青光眼眼压降低前后视盘改变和筛板顺应性的对比研究[J]. 眼科, 2009, 18(4): 264-269.