Clinical application of a bioactive nano-hydroxyapatite/polyamide 66 interbody fusion cage

doi:10.3969/j.issn.2095-4344.2013.34.018

Abstract

Abstract:

BACKGROUND: There are various commonly used interbody fusion methods, such as autologous bone, allograft bone and titanium-based posterior lumbar interbody fusion, and each method has its own advantages and disadvantages.

OBJECTIVE: To observe the clinical efficacy of a bioactive nano-hydroxyapatite/polyamide 66 fusion cage in posterior lumbar interbody fusion for the treatment of lumbar disease.

METHODS: A retrospective case analysis was conducted on 16 cases treated with posterior lumbar interbody fusion at the Department of Orthopedic, the First Affiliated Hospital of Gannan Medical University from July 2010 to December 2011, and all the patients were implanted with nano-hydroxyapatite/polyamide 66 biological activity fusion cage.

RESULTS AND CONCLUSION: All the patients were followed-up for 10-24 months, and the lumbar pain was significant improved, the lumbar visual analogue score, lumbar Japanese Orthopaedic Association score and Oswestry disability index score were significantly improved during the final follow-up period (P < 0.05). No internal fixation loosing or broken observed in all the patients during final follow-up, and all the patients obtained bone fusion without nano-hydroxyapatite/polyamide 66 fusion cage displacement or subsidence. The results indicate that nano-hydroxyapatite/polyamide 66 fusion cage for the treatment of posterior lumbar interbody fusion can reconstruct the lumbar stability and provide immediate stability after implantation, and has good biological activity.

Key words: biomaterials, nanobiomaterials, orthopedic biomaterials, nano-hydroxyapatite, polyamide 66, interbody fusion cage, interbody fusion, biocompatibility

CLC Number:

R318

Wang Mao-yuan, Xie Rui-lian, He Chun-lei, Liu Wu-yang, Huang Wei-min, Gao Hui . Clinical application of a bioactive nano-hydroxyapatite/polyamide 66 interbody fusion cage[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(34): 6179-6182.

Figures/Tables 1

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