Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (8): 1349-1353.doi: 10.3969/j.issn.2095-4344.2013.08.004

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Injectable bone regeneration composite in combination with assemble flavone of rhizome drynaria repairs rat skull defects

Li Jin-yu1, Jin He2, Yu Xing1, Xu Lin1   

  1. 1 Department of Orthopedics, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
    2 Department of Orthopedics, Yanqing Chinese Medicine Hospital, Beijing 102100, China
  • Received:2012-10-18 Revised:2012-11-28 Online:2013-02-19 Published:2013-02-19
  • Contact: Yu Xing, Chief physician, Professor, Doctoral supervisor, Department of Orthopedics, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China yuxing34@sina.com
  • About author:Li Jin-yu★, Master, Attending physician, Department of Orthopedics, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China leery_5566@163.com

Abstract:

BACKGROUND: Autogenous iliac bone graft has been considered as the “gold standard” for repair of bone defects, but its resource is limited.
OBJECTIVE: To analyze the effect of injectable bone regeneration composite (IBRC) combined withassemble flavone of rhizome drynaria (AFDR) in the repair of rat skull defects.
METHODS: Eighty male Sprague-Dawley rats were randomly arranged into three groups, and rats in each group were intragastrically administered with IBRC+AFDR, IBRC+deionized water, and hydroxyapatite+deionized water, respectively. Treatment was performed once a day, lasting for 8 weeks. Skull samples were taken for hematoxylin-eosin and Masson staining at 2, 4, and 8 weeks after modeling.
RESULTS AND CONCLUSION: New bone formation and material degradation were slower in the hydroxyapatite+ deionized water group than the IBRC+AFDR and IBRC+deionized water groups. IBRC was beneficial for the in-growth of vessels and fibers. Intragastric administration of AFDR could induce bone formation through improving the growth of vessels and fibers into the implant. IBRC+AFDR can promote bone formation and shorten repair time during the repair of rat skull defects.

Key words: biomaterials, tissue engineering bone materials, injectable bone regeneration composite, bone defects, skull, assemble flavones of rhizome drynaria, drynaria, total flavonoids, hydroxyapatite, degradation, deionized water, microvessels, ministry grants-supported paper, biomaterial photographs-containing paper

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