Abstract:

BACKGROUND: Tricalcium phosphate bone as a kind of graft material has been widely used in clinic, but most studies are in vitro studies, animal models research and clinical analysis.
OBJECTIVE: To observe the bone histological changes after the treatment of distal tibial fractures using the porous tricalcium phosphate.
METHODS: Patients with distal fibular fracture were treated by open reduction and internal fixation. Part of the patients underwent bone grafting using the tricalcium phosphate, and the degradation of specimens was observed after treatment. The internal fixator was obtained during the second operation after bone healing, and a small amount of bone samples were obtained from the original bone graft area for the second histological observation and comparison of growth of osteocytes.
RESULTS AND CONCLUSION: Bone samples exhibited active proliferating osteoblasts in new bone tissue, differentiated and mature osteocytes with increased density, trabeculae with increased density, and fibrous tissue with capillary proliferation between trabeculae. Bone defects filled with porous tricalcium phosphate has many advantages, such as the well new bone formation, strong cell proliferation ability and good biocompatibility.