Prediction of hip fracture in Parkinson’s disease with the combination of geometric structure of proximal femur and bone mineral density

doi:10.3969/j.issn.2095-4344.1232

Abstract

Abstract:

BACKGROUND: Patients with Parkinson’s disease have a high risk of falls and low bone density, so the incidence of fracture increases. It is important to understand the risk factors associated with hip fracture and predict risk.

OBJECTIVE: To investigate the variations of hip bone mineral density and geometric structure of proximal femur in patients with Parkinson’s disease, and to predict the risk for hip fracture.

METHODS: Sixty-two cases of Parkinson’s disease and 70 cases of osteoporotic non-Parkinson’s disease at the First People’s Hospital of Fuzhou as Parkinson’s disease group were collected from the First People’s Hospital of Fuzhou, and 90 healthy controls matched for sex and age were enrolled. All patients assigned the informed consents, and the study was approved by the Ethics Committee of the First People’s Hospital of Fuzhou. The bone mineral density and geometric structure parameters of proximal femur were measured by dual-energy X-ray absorptiometry and hip structural analysis software and their correlations were analyzed by Pearson correlation analysis.

RESULTS AND CONCLUSION: (1) There was no significant difference in the neck shaft angle and cross-sectional moment among groups (P > 0.05). (2) The Parkinson’s disease group had decreased cross sectional area and cortical thickness, and increased upper buckling ratio compared with the non-Parkinson’s disease and healthy control groups (P < 0.05). (3) Bone mineral density showed positive correlation with cross sectional area and cortical thickness, and showed negative correlation with bucking ratio (P < 0.01). Bone mineral density had no correlation with neck shaft angle and cross-sectional moment of inertia both (both P > 0.05). (4) These results indicate that Parkinson’s disease patients have low bone mineral density, decreased cross sectional area and cortical thickness, and high upper buckling ratio, which may increase the risk for hip fracture. Incidence of hip fracture is associated with the bone mineral density of hip and changed geometric structure of proximal femur.

Key words: Parkinson’s disease, hip fracture, bone mineral density, geometric structure of proximal femur, Pearson correlation analysis, femoral neck shaft angle, cross-sectional moment, cortical thickness

CLC Number:

R459.9

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R459.9

Wang Wuhua, Liu Xudong, Hu Ling. Prediction of hip fracture in Parkinson’s disease with the combination of geometric structure of proximal femur and bone mineral density [J]. Chinese Journal of Tissue Engineering Research, 2019, 23(24): 3829-3833.

Figures/Tables 3

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