Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (5): 919-922.doi: 10.3969/j.issn.1673-8225.2012.05.037

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Effect of soluble N-ethylmaleimide-sensitive factor attachment protein receptor on the immunological function of macrophages

Wang Rui-heng1, Wan Ying2   

  1. 1Plastic and Reconstructive Surgery, Southwest Hospital, the Third Military Medical University of Chinese PLA, Chongqing  400038, China; 2Testing Center of Biomedical Analysis, the Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2011-11-15 Revised:2011-12-15 Online:2012-01-29 Published:2012-01-29
  • Contact: Wan Ying, Doctor, Professor, Testing Center of Biomedical Analysis, the Third Military Medical University of Chinese PLA, Chongqing 400038, China ying.wan1972@gmail.com
  • About author:Wang Rui-heng☆, Doctor, Plastic and Reconstructive Surgery, Southwest Hospital, the Third Military Medical University of Chinese PLA, Chongqing 400038, China ruiheng.wang1986@gmail.com

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Abstract:

BACKGROUND: Macrophage performs the antigen phagocytosis, secretion of cytokines and migration through vesicle transport. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) is a family of proteins which mediate the transportation of vesicles.
OBJECTIVE: To thoroughly understand the effects of SNARE proteins on the immune activities of macrophage and the function.
METHODS: An online search of PubMed, Embase and VIP databases (2011-11) was performed using key words of “SNARE proteins, macrophages” for articles published in English or Chinese. The irrelevant or repetitive papers were eliminated by screening for the titles and abstracts. Some essential articles that were helpful for understanding its mechanism were supplemented.
RESULTS AND CONCLUSION: A total of 27 articles were included. SNARE family is the molecular basis to ensure the direct transportation of vesicles and accurate unloading, and plays a role in antigen phagocytosis of macrophages, cytokine secretion and migration. It is a reasonable strategy for research the immune activity of macrophages with the starting point of SNARE family.  

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