Abstract:

BACKGROUND: The key for the survival of the transplant kidney is to provide regularly renal biopsy, correct pathological diagnosis and appropriate treatment for the recipients in the early stage when the problems of the transplant kidney are discovered.
OBJECTIVE: To summarize the pathology performance and changes of kidney necrosis and rejection after kidney transplant.
METHODS: A computer-based online search of VIP Database and PubMed database was performed for the relevant articles on kidney necrosis and rejection after kidney transplant published from January 1998 to October 2009. The collected articles were preliminarily reviewed; the references of each article were checked.
RESULTS AND CONCLUSION: A total of 16 articles were retained according to the inclusion criteria. The pathological types of chronic kidney damage after transplantation include chronic rejection, mesangial lesions, crescentic glomerulonephritis, membranous nephropathy, Ig nephropathy and hemolytic uremic syndrome. Chronic rejection is the most common pathological type of chronic kidney damage after transplantation; the factors related to chronic rejection may include: donor age, the incidence of acute rejection, delayed graft function recovery and CMV infection. Hypertension and proteinuria have important effects on the long-term prognosis of transplanted kidney. Pathological changes in transplanted kidney are complex and diverse; the combined diagnosis method based on the results of renal puncture biopsy and clinical analysis has high success rate and good safety. It has an important guiding sense to the judgments of kidney damage after renal transplantation based on clinical laboratory data and the selection of treatment options.