Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9648-9650.doi: 10.3969/j.issn.1673-8225.2011.51.035

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Biocompatibility and clinical application of silk fibroin

Zhao Guang-jian1, Zhao Yao2   

  1. 1Department of Medical Teaching, 2Department of Nephropathy, Affiliated Hospital of Armed Police Rear Service Institute, Tianjin 300162, China
  • Received:2011-10-17 Revised:2011-11-17 Online:2011-12-17 Published:2011-12-17
  • About author:Zhao Guang-jian, Associate professor, Associate chief physician, Department of Medical Teaching, Affiliated Hospital of Armed Police Rear Service Institute, Tianjin 300162, China guangjianzhao@ yahoo.cn

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Abstract:

BACKGROUND: Repair and reconstruction after skin injury are difficult. It is an ideal approach to repair defects using skin cells to restore tissue and organ appearance and function. However, this problem remains resolving in clinic.
OBJECTIVE: To summarize biocompatibility and application advances in silk fibroin to search the optimal artificial skin.
METHODS: A computer-based online search of CNKI and PubMed database was performed for articles related to biocompatibility of silk fibroin and its application in tissue engineered skin and biomaterials, with key words “silk fibroin; biocompatibility; tissue engineering; biological materials; application” in Chinese and English. Articles published recently in authoritative journals regarding biocompatibility and application of silk fibroin were selected. 215 articles were collected and 22 were included.
RESULTS AND CONCLUSION: Understanding of properties and application of silk fibroin can benefit repair and reconstruction after skin injury. Repairing defects using skin cells to restore tissue and organ appearance and function exhibits mechanical performance and physiochemical properties, as well as biocompatibility. Moreover, it can promote epidermic cell growth. However, some issues need to resolve for clinical treatment.

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