Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9513-9517.doi: 10.3969/j.issn.1673-8225.2011.51.004

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A type of injectable porous calcium phosphate cement in vivo

Zhang Liang1, Gao Jian-jun2, Dang Xiao-qian3   

  1. 1Department of Orthopaedics, Xi’an Hong Hui Hospital, Xi’an Jiaotong University, Xi’an  710054, Shaanxi Province, China
    2Department of Orthopaedics, Hospital of Yangling Demonstration Area, Yangling  712100, Shaanxi Province, China
    3First Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an  710078, Shaanxi Province, China
  • Received:2011-04-20 Revised:2011-07-18 Online:2011-12-17 Published:2011-12-17
  • Contact: Dang Xiao-qian, Doctor, Professor, First Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710078, Shaanxi Province, China dang_xiaoqian@ sohu.com
  • About author:Zhang Liang, Attending physician, Department of Orthopaedics, Xi’an Hong Hui Hospital, Xi’an Jiaotong University, Xi’an 710054, Shaanxi Province, China glowthy@ sina.com.cn

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Abstract:

BACKGROUND: Calcium phosphate cement (CPC) has the disadvantages of brittleness, low waterborne (blood-soluble), poor mechanical property and conductibility which limit its clinical application in some degree. Therefore its modification research is in need.
OBJECTIVE: To prepare a type of porous calcium phosphate cement with certain intensity and porosity for the bone growth.
METHODS: This study was based on the CPC system. The liquid phase was the weak acidic solution of chitosan which had favorable biocompatibility and high viscosity to achieve injectable of CPC. It could strongly improve the application and comfort of CPC. The solid phase was biphasic calcium phosphate (four calcium phosphate + calcium hydrogen phosphate) system. The pores of mannitol and lactic-co-glycolic acid were added into solid phase to prepare the calcium phosphate scaffold.
RESULTS AND CONCLUSION: The aperture of the prepared material could reach to 10-300 μm. The porosity of the solidified CPC could reach to (68.3±1.5)% when the proportion of the porogen was 60%. The increased porosity of CPC decreased the mechanical properties of the material, the compressive strength of CPC without porogen was (53.0±1.4) MPa initially, and dropped to (2.5±0.2) MPa with 60% porogen. The CPC material has better compressive strength and favorable biocompatibility, and can be degraded in vivo and used as a type of injectable scaffold materials.

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