Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (50): 9491-9495.doi: 10.3969/j.issn.1673-8225.2011.50.044

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Polymorphism of G protein β3 subunit 825C/T in Korean population and Han population with essential hypertension in Mudanjiang region

Song Jie1, Lu Shuang2, Gao Xiao-hong3, Zhang Shu-jie1   

  1. 1Department of Biology, Mudanjiang Medical University, Mudanjiang  157011, Heilongjiang Province, China; 2Department of Cardiology, Koreans Hospital of Mudanjiang City, Mudanjiang  157000, Heilongjiang Province, China; 3Biotechnology Laboratory, Mudanjiang Medical University, Mudanjiang  157011, Heilongjiang Province, China
  • Received:2011-05-19 Revised:2011-09-26 Online:2011-12-10 Published:2011-12-10
  • About author:Song Jie☆, Doctor, Associate professor, Department of Biology, Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China 0453sj@163.com
  • Supported by:

    the Scientific Research Program of Education Bureau of Heilongjiang Province, No. 11531364*

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Abstract:

BACKGROUND: Whether there is a relationship between the gene polymorphisms of G-protein β3 subunit 825 C/T and the primary hypertension of Korean population remains unanswered.
OBJECTIVE: To explore the gene polymorphisms of C825T in Korean population and Han population with essential hypertensive in Mudanjiang.
METHODS: A total of 224 essential hypertensive patients receiving medical serving in the Internal Medicine Department of Koreans Hospital of Mudanjiang City were selected as hypertension group. A number of 196 healthy people underwent physical examinations in the corresponding period at the clinic were selected as normotensive group. PCR-RFLP method was used to measure the polymorphism of G-protein β3 subunit C825T. Genotype frequencies and allele frequencies of TT, TC and CC were investigated.
RESULTS AND CONCLUSION: PCR-RFLP results demonstrated that with respect to Korean population in Mudanjiang, there was no significant difference in the genotype frequencies of TT, TC and CC between the hypertension group and normotensive group (P < 0. 05), and there was significant difference in the allele frequencies of T and C between these two groups (P < 0. 05). With respect to Han population in Mudanjiang, there was significant difference in the genotype frequencies of TT, TC and CC between the hypertension group and normotensive group (P < 0.05), but no significant differences in allele frequencies of T and C between these two groups (P > 0.05). Allele frequency of C in hypertension group of Korean population was higher while the allele frequency of T was higher in hypertension group of Han population. There was a difference between nations. These findings indicate that the gene polymorphisms of G-protein β3 subunit C825T is not related to hypertension of Korean population in Mudanjiang, but is a risk factor of hypertension in Mudanjiang Han population.

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