Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (50): 9462-9465.doi: 10.3969/j.issn.1673-8225.2011.50.037

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Effect of astragalus polysaccharide on cellular immunity of rats with recurrent aphthous ulcer

Wang Xue-mei1, Bo Lei1, Li Xin2, Zhang Ju-mei1, Yu Zhan-hai1   

  1. 1School of Stomatology, Lanzhou University, Lanzhou  730000, Gansu Province, China
    2Air-force Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730000, Gansu Province, China
  • Received:2011-05-27 Revised:2011-08-01 Online:2011-12-10 Published:2011-12-10
  • Contact: Yu Zhan-hai, Doctor, Professor, School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China yuzhanhai@lzu.edu.cn
  • About author:Wang Xue-mei, Lecturer, School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China w_xuemei@hotmail.com

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Abstract:

BACKGROUND: Recurrent aphthous ulcer is caused by complicated factors. It may be related to the imbalance of immune regulation.
OBJECTIVE: To investigate the relationship between the abnormal cellular immune and the pathogenesis of recurrent aphthous ulcer and to explore the immune regulation of astragalus polysaccharide in rats with recurrent aphthous ulcer.
METHODS: Immunization method was used to establish recurrent aphthous ulcer model in SD rats. Rats were treated with 100, 200 and 300 mg/kg astragalus polysaccharide or saline by gavage after model establishment. Rats receiving normal feeding were used as control. The values of peripheral blood T lymphocyte subsets CD4+, CD8+ and CD4+/CD8+ in SD rats of each group were measured by flow cytometry.
RESULTS AND CONCLUSION: According to flow cytometry, the values of peripheral blood CD4+ and CD4+/CD8+ decreased significantly in rats with recurrent aphthous ulcer, while the value of CD8+ increased significantly (P < 0.05). On the 20th day after treated with 100, 200 and 300 mg/kg astragalus polysaccharide by gavage, the values of peripheral blood CD4+ and CD4+/CD8+ partially recovered in rats with recurrent aphthous ulcer, expecially in the rats treated with 300 mg/kg astragalus polysaccharide. It demonstrates that the unbalance of T-lymphocyte is related to the pathogenesis of recurrent aphthous ulcer. Astragalus polysaccharide can dose-dependently improve the abnormal immune state in rats with recurrent aphthous ulcer.

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