Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (50): 9311-9313.doi: 10.3969/j.issn.1673-8225.2011.50.001

    Next Articles

Relationship between synovium pathological change and injection timing in rabbits with papain-induced knee osteoarthritis

Sun Lu-ning1, 2, Zhao Yan-hua1, Huang Gui-cheng1, Xia Jian-long1   

  1. 1Nanjing University of Chinese Medicine, Nanjing  210029, Jiangsu Province, China
    2Department of Orthopedic Surgery, Jiangsu Hospital of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
  • Received:2011-08-05 Revised:2011-09-06 Online:2011-12-10 Published:2011-12-10
  • Contact: Sun Lu-ning, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China; Department of Orthopedic Surgery, Jiangsu Hospital of Taditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China sunluning2000@sina.com
  • About author:Sun Lu-ning★, Master, Associate chief physician, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China; Department of Orthopedic Surgery, Jiangsu Hospital of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China sunluning2000@sina.com

PDF

684

Abstract:

BACKGROUND: A stable degenerative knee osteroarthritis model in rabbits can be established by the induction of papain.
OBJECTIVE: To explore the relationship between the pathological change of synovium and injection timing in rabbits with knee osteoarthritis induced by intraarticular injection of papain.
METHODS: Papain solution was injected into the right knee joint cavity of 15 New Zealand white rabbits on the 1st, 4th and 7th days to induce knee osteoarthritis in rabbits . The general and histopathologic changes of knee synovium were examined in the 2nd, 4th and 6th weeks after first injection. Five rabbits were examined at each time point.
RESULTS AND CONCLUSION: The synovium inflammatory reaction of rabbit knee joint was the most serious at the 2nd week after the first injection of papain, characterized by the most obvious proliferation of synovial cell, obvious proliferation of vascular tissue and substratum porosity fiber vascular tissue, visible infiltration of many lymphoplasmacytoid cells. The inflammatory reaction relieved gradually in the 4th and 6th weeks. These results illustrate that the synovium inflammatory reaction of knee joint in rabbits reach its maximum effect in the 2nd week after the first injection of papain.

CLC Number: