Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (49): 9291-9294.doi: 10.3969/j.issn.1673-8225.2011.49.040

Previous Articles     Next Articles

Stem cells transplantation for treatment of diabetes mellitus

Li Xue, Chen Qiu   

  1. Department of Endocrinology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu  610075, Sichuan Province, China
  • Received:2011-05-20 Revised:2011-06-21 Online:2011-12-03 Published:2011-12-03
  • Contact: Chen Qiu, Doctor, Master’s supervisor, Professor, Department of Endocrinology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China chenqiu1969@yahoo.com.cn
  • About author:Li Xue★, Studying for master’s degree, Department of Endocrinology, the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China 83908325@qq.com
  • Supported by:

    the Applied Basic Research Fund of Sichuan Province & Sichuan Health Bureau*

PDF

428

Abstract:

BACKGROUND: Stem cells transplantation can treat diabetes mellitus on cell and gene levels to achieve clinical cure.
OBJECTIVE: To review the research progress addressing stem cells transplantation for diabetes mellitus.
METHODS: A computer based search was conducted in PubMed database and Chinese Journal Full-text database for relevant articles published from January 2000 to June 2010, with keywords of “stem cells, diabetes mellitus, transplantation, insulin-secreting cell, treatment” in English and Chinese, respectively. A total of 27 articles were reviewed.
RESULTS AND CONCLUSION: Diabetes mellitus is a group of metabolic disease characterized by chronic high blood sugar, which is caused by absolute or relative deficiency of insulin. Currently there is no treatment to cure it. Stem cells have a strong self-renewal and differentiation potential, which can be induced to differentiate into insulin-secreting cells to regulate blood sugar in vivo and in vitro, and they become the new resource of a substitute of islet β cells. At present, stem cells transplantation on treatment of diabetes mellitus has made some progress in animal experiments and small-scale clinical studies.

CLC Number: